Unassociated Document

 
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.  20549
 


FORM 6-K

Report of Foreign Private Issuer
Pursuant to Rule 13a-16 or 15d-16
of the Securities Exchange Act of 1934

For the month of May 2010

Commission File Number 000-28508

Flamel Technologies
(Translation of registrant's name into English)

Parc Club du Moulin à Vent
33 avenue du Dr. Georges Levy
69693 Vénissieux Cedex France
(Address of principal executive offices)

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.

Form 20-F x            Form 40-F ¨

Indicate by check mark whether registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.

Yes ¨            No x

If "Yes" is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2(b):  82-____________
 
 
 

 
 

 
INFORMATION FILED WITH THIS REPORT
 
Document Index
 
99.1
 
Notice of a Combined Ordinary and Extraordinary Meeting of Shareholders on June 25, 2010.
     
99.2
 
Draft Resolutions to be submitted at the Ordinary and Extraordinary General Shareholders’ Meeting on June 25, 2010.
     
99.3
 
Management Report prepared by the Board of Directors to be presented at the Annual Ordinary Shareholders’ Meeting on June 25, 2010.
     
99.4
 
Board Report to be submitted at the Combined Shareholders’ Meeting on June 25, 2010.
     
99.5
 
Form of Proxy to Shareholders.
     
99.6
 
Form of Proxy to ADS Holders.
     
99.7
 
Document and Information Request Form.
 
 
 

 


 
SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

 
Flamel Technologies, S.A.
   
     
Dated: 27 May, 2010
By:
/s/ Stephen H. Willard
 
Name:  Stephen H. Willard
 
Title:  Chief Executive Officer

 
 

 
 

EXHIBIT INDEX

 
Exhibit
Number
 
Description
     
99.1
 
Notice of a Combined Ordinary and Extraordinary Meeting of Shareholders on June 25, 2010.
     
99.2
 
Draft Resolutions to be submitted at the Ordinary and Extraordinary General Shareholders’ Meeting on June 25, 2010.
     
99.3
 
Management Report prepared by the Board of Directors to be presented at the Annual Ordinary Shareholders’ Meeting on June 25, 2010.
     
99.4
 
Board Report to be submitted at the Combined Shareholders’ Meeting on June 25, 2010.
     
99.5
 
Form of Proxy to Shareholders.
     
99.6
 
Form of Proxy to ADS Holders.
     
99.7
 
Document and Information Request Form.

 
 
 

 

- Translated from French –

FLAMEL TECHNOLOGIES
Société Anonyme with a share capital of Euros 2,973,702
Registered Office :
Parc Club du Moulin à Vent
33, avenue du Docteur Georges Lévy
69693 VENISSIEUX (France)
 
379 001 530 R.C.S. LYON
 

NOTICE OF A COMBINED ORDINARY AND EXTRAORDINARY GENERAL
MEETING OF SHAREHOLDERS
ON JUNE 25, 2010

Sent by Mail on May 27, 2010

Ladies and Gentlemen,

You are cordially invited to attend the Combined Ordinary and Extraordinary General Meeting (the “Meeting”) of the shareholders of FLAMEL TECHNOLOGIES (the “Company”) which will be held on June 25, 2010 at 11:00 a.m. (French time) at the registered office of the Company, with the following agenda :

Agenda

Resolutions within the competence of the ordinary general shareholders’ meeting

 
1.
Approval of Statutory Accounts for year ended December 31, 2009.
 
 
2.
Allocation of results to retained earnings.
 
 
3.
Renewal of Mr. Elie Vannier as Director.
 
 
4.
Renewal of Mr. Frederic Lemoine as Director.
 
 
5.
Renewal of Mr. Lodewijk J.R. De Vink as Director.
 
 
6.
Renewal of Mr. John L. Vogelstein as Director.
 
 
7.
Renewal of Mr. Francis JT Fildes as Director.
 
 
8.
Renewal of Mr. Stephen H. Willard as Director.
 
 
9.
Determination of the annual amount of Directors’ attendance fees.
 
 
10.
Approval of agreements referred to in article L. 225-38 et seq. of the Commercial Code.

 
1

 

- Translated from French –

Resolutions within the competence of the extraordinary general shareholders’ meeting

 
11.
Authorization to be granted to the Board of Directors for allocation of seven hundred and fifty thousand (750,000) stock options and taking note of the resulting capital increases.
 
 
12.
Authorization to be granted to the Board of Directors with a view to allocation of two hundred thousand (200,000) shares at no cost (“free shares”) and taking note of the resulting capital increases.
 
 
13.
Authorization to be granted to the Board of Directors for issue of a maximum number of two hundred and fifty thousand (250,000) stock warrants (BSA) reserved for a category of persons consisting of the company’s directors who are neither authorized agents nor employees of the company, but including the Chairman of the Board of Directors; authorization to be granted to the Board of Directors for carrying out the resulting capital increases.
 
 
14.
Authorization to be granted to the Board of Directors for increasing the share capital by issues of shares reserved for the members of a company saving plan established in application of Articles L.3332-18 et seq. of the Labour Code.
 
 
15.
Powers for formalities.

Please note that in the event that you are not able to attend the meeting, you may either grant a proxy to your spouse or to another shareholder, who will be attending the meeting, or vote by mail.  You may also address a proxy to the Company without indicating any representative.
 In this latter case, please note that the Chairman of the meeting will thus (i) vote in favor of the resolutions approved by the Board of Directors and (ii) vote unfavorably for the other resolutions, which would have not been approved by the Board.

 If you wish to vote in another way, you shall give a proxy to a representative, who will agree to vote as you require.

Under no circumstances will you be allowed to return to the Company a document including both instructions of vote by mail and by proxy.

The voting instructions will not be taken into account unless the above-mentioned document, duly filled out, reaches the Company at least three days before the Shareholders' meeting.

ON BEHALF OF THE BOARD OF DIRECTORS

 
2

 

- Translated from French –

IMPORTANT :

IF YOU EXPECT TO BE PRESENT AT THE MEETING, PLEASE NOTE THAT SHAREHOLDERS WILL BE ADMITTED TO THE COMBINED ORDINARY AND EXTRAORDINARY GENERAL MEETING WITH WHATEVER THE NUMBER OF SHARES THEY HOLD PROVIDED THAT IF THEY ARE OWNER OF REGISTERED SHARES THEIR SHARES HAVE BEEN REGISTERED IN A SHARE ACCOUNT HELD BY THE COMPANY AT LEAST ONE DAY PRIOR TO THE DATE OF THE MEETING.

IF YOU EXPECT NOT TO BE PRESENT AT THE MEETING, YOU MAY COMPLETE AND PROMPTLY RETURN THE FORM OF PROXY AND VOTE BY MAIL (“DOCUMENT UNIQUE DE VOTE PAR CORRESPONDANCE ET PAR PROCURATION”), WHICH IS ENCLOSED FOR YOUR CONVENIENCE.

PLEASE NOTE THAT ANY ABSTENTION EXPRESSED IN THE FORM OF PROXY AND VOTE BY MAIL (“DOCUMENT UNIQUE DE VOTE PAR CORRESPONDANCE ET PAR PROCURATION”) OR RESULTING FROM THE ABSENCE OF INDICATION OF VOTE WILL BE DEEMED TO BE AN UNFAVORABLE VOTE TO THE PROPOSED RESOLUTION.

IF THE QUORUM FOR THE ORDINARY MEETING IS NOT MET ON JUNE 25, 2010, SHAREHOLDERS WILL BE INVITED TO VOTE AT A MEETING WHICH WILL BE HELD ON JULY 2, 2010 ON THE SAME AGENDA, AS DESCRIBED IN THIS NOTICE .

Quorum required under French law :

The required quorum for ordinary resolutions is one fifth (20%) of the total outstanding shares. If such quorum is not met, the Board of Directors will give a second notice of Shareholders’ Meeting.
At this second Meeting, no quorum is required for ordinary resolutions.

The required quorum for extraordinary resolutions is one fourth (25%) of the total outstanding shares with voting rights, upon first call of the shareholders' meeting.  If such quorum is not met, the Board of Directors will give a second notice of Shareholders’ Meeting. At this second Meeting,which shall not take place earlier than six days after the first meeting, the required quorum is one fifth (20%) of the total outstanding shares with voting rights.

Enclosed documents:

§
Resolutions submitted to the combined ordinary and extraordinary shareholders' meeting to be held on June 25, 2010;
§
Management Report by the Board of Directors to the ordinary shareholders’ meeting including notably (Appendix 1) table of the Company's results for the last five financial years;
§
Report by the Board of Directors  to the combined shareholders meeting held on June 25, 2010;
§
Form of proxy and vote by mail;
§
Document and information request form.

 
3

 
 
Translated from French
 
FLAMEL TECHNOLOGIES
Société Anonyme with a stated capital of 2,973,702 euros
Registered Office:
Parc Club du Moulin à Vent
33, avenue du Docteur Georges Lévy
69693 VENISSIEUX – France
 
379 001 530 R.C.S. LYON
 
RESOLUTIONS SUBMITTED TO THE ORDINARY AND EXTRAORDINARY
GENERAL SHAREHOLDERS’ MEETING
TO BE HELD ON JUNE 25, 2010
 

 
WITHIN THE COMPETENCE OF THE ORDINARY GENERAL SHAREHOLDERS’
MEETING

 
1.
Approval of Statutory Accounts for year ended December 31, 2009.
 
 
2.
Allocation of results to retained earnings.
 
 
3.
Renewal of Mr. Elie Vannier as Director.
 
 
4.
Renewal of Mr. Frederic Lemoine as Director.
 
 
5.
Renewal of Mr. Lodewijk J.R. De Vink as Director.
 
 
6.
Renewal of Mr. John L. Vogelstein as Director.
 
 
7.
Renewal of Mr. Francis JT Fildes as Director.
 
 
8.
Renewal of Mr. Stephen H. Willard as Director.
 
 
9.
Determination of the annual amount of Directors’ attendance fees.
 
 
10.
Approval of agreements referred to in article L. 225-38 et seq. of the Commercial Code.
 
WITHIN THE COMPETENCE OF THE EXTRAORDINARY GENERAL
SHAREHOLDERS’ MEETING
 
 
11.
Authorization to be granted to the Board of Directors for allocation of seven hundred and fifty thousand (750,000) stock options and taking note of the resulting capital increases.
 
 
12.
Authorization to be granted to the Board of Directors with a view to allocation of two hundred thousand (200,000) shares at no cost (“free shares”) and taking note of the resulting capital increases.
 
 
13.
Authorization to be granted to the Board of Directors for issue of a maximum number of two hundred and fifty thousand (250,000) stock warrants (BSA) reserved for a category of persons consisting of the company’s directors who are neither authorized agents nor employees of the company, but including the Chairman of the Board of Directors; authorization to be granted to the Board of Directors for carrying out the resulting capital increases.

 
1

 
 
Translated from French
 
  
14.
Authorization to be granted to the Board of Directors for increasing the share capital by issues of shares reserved for the members of a company saving plan established in application of Articles L.3332-18 et seq. of the Labour Code.
 
 
15.
Powers for formalities.
  


- RESOLUTIONS WITHIN THE COMPETENCE OF THE ORDINARY GENERAL
SHAREHOLDERS’ MEETING –

FIRST RESOLUTION

Approval of Statutory Accounts for year ended December 31, 2009

The General Shareholders' Meeting, voting under the quorum and majority conditions for ordinary general meetings,

after having taken cognizance of the financial statements for the fiscal year ended on December 31, 2009, and having heard a reading of the Board of Directors’ management report and of the general report of the Statutory Auditor pertaining to said fiscal year,

approves, in their entirety, the said financial statements as they have been presented to it, as well as the transactions recorded in such financial statements and reports, which show a benefit in the amount of 1,270,699.00 €.

Accordingly, the General Shareholders' Meeting grants the Directors full discharge for the performance of their duties during said fiscal year.

Furthermore and in accordance with Section 223 quater of the General Tax Code, the General Shareholders' Meeting acknowledges that non tax-deductible expenses or charges as set forth at Section 39-4 of the General Tax Code were incurred for a total of 22,891.00 € Euros during the fiscal year ended December 31, 2009 corresponding to excess redemption.

SECOND RESOLUTION

Allocation of results to retained earnings

The General Shareholders' Meeting, voting under the quorum and majority conditions for ordinary general meetings,

After having heard a reading of the Board of Directors’ management report, decides to allocate the benefit for the financial year ended on December 31, 2009, amounting to 1,270,699.00 €, to the carry forward account, which will then amount to (95,954,953)Euros.

 
2

 
 
Translated from French
 
It is recalled, pursuant to article 243 bis of the General Tax Code, that no dividend was distributed for the fiscal years ended December 31, 2009, December 31, 2008 and December 31, 2007.

THIRD RESOLUTION

Renewal of a Director

The General Shareholders' Meeting, voting under the quorum and majority conditions for ordinary general meetings,

After having heard a reading of the Board of Directors' management report, acknowledging that the term of the Director’s office of Elie Vannier expires at the end of this meeting,

Decides to renew his office for one (1) year, to expire at the end of the General Shareholders’ Meeting convened to approve the financial statements for the fiscal year ending December 31, 2010.

Elie Vannier has declared that he complied with all the conditions required by applicable laws and regulations in order to hold such office.

FOURTH RESOLUTION

Renewal of a Director

The General Shareholders' Meeting, voting under the quorum and majority conditions for ordinary general meetings,

After having heard a reading of the Board of Directors' management report, acknowledging that the term of the Director’s office of Frédéric Lemoine expires at the end of this meeting,

Decides to renew his office for one (1) year, to expire at the end of the General Shareholders’ Meeting convened to approve the financial statements for the fiscal year ending December 31, 2010.

Frédéric Lemoine has declared that he complied with all the conditions required by applicable laws and regulations in order to hold such office.

FIFTH RESOLUTION

Renewal of a Director

The General Shareholders' Meeting, voting under the quorum and majority conditions for ordinary general meetings,

 
3

 
 
Translated from French
 
After having heard a reading of the Board of Directors' management report, acknowledging that the term of the Director’s office of Lodewijk J.R. De Vink expires at the end of this meeting,

Decides to renew his office for one (1) year, to expire at the end of the General Shareholders’ Meeting convened to approve the financial statements for the fiscal year ending December 31, 2010.

Lodewijk J.R. De Vink has declared that he complied with all the conditions required by applicable laws and regulations in order to hold such office.

SIXTH RESOLUTION

Renewal of a Director

The General Shareholders' Meeting, voting under the quorum and majority conditions for ordinary general meetings,

After having heard a reading of the Board of Directors' management report, acknowledging that the term of the Director’s office of John L. Vogelstein expires at the end of this meeting,

Decides to renew his office for one (1) year, to expire at the end of the General Shareholders’ Meeting convened to approve the financial statements for the fiscal year ending December 31, 2010.

John L. Vogelstein has declared that he complied with all the conditions required by applicable laws and regulations in order to hold such office.

SEVENTH RESOLUTION

Renewal of a Director

The General Shareholders' Meeting, voting under the quorum and majority conditions for ordinary general meetings,

After having heard a reading of the Board of Directors' management report, acknowledging that the term of the Director’s office of Francis JT Fildes expires at the end of this meeting,

Decides to renew his office for one (1) year, to expire at the end of the General Shareholders’ Meeting called on to approve the financial statements for the fiscal year ending December 31, 2010.

Francis JT Fildes has declared that he complied with all the conditions required by applicable laws and regulations in order to hold such office.

 
4

 
 
Translated from French
  
EIGHTH RESOLUTION

Renewal of a Director

The General Shareholders' Meeting, voting under the quorum and majority conditions for ordinary general meetings,

After having heard a reading of the Board of Directors' management report, acknowledging that the term of the Director’s office of Stephen H. Willard expires at the end of this meeting,

Decides to renew his office for one (1) year, to expire at the end of the General Shareholders’ Meeting called on to approve the financial statements for the fiscal year ending December 31, 2010.

Stephen H. Willard has declared that he complied with all the conditions required by applicable laws and regulations in order to hold such office.

NINTH RESOLUTION

Determination of the annual amount of Directors’ attendance fees

After having heard a reading of the Board of Directors' management report, the General Shareholders’ Meeting voting under the quorum and majority conditions for ordinary general meetings,

Decides to allocate to the Board of Directors, under condition of adoption of resolution three to eight, a maximum aggregate amount of three hundred and twenty five thousand (325,000) euros as annual attendance fees (jetons de presence) for the fiscal year ending December 31, 2010.

The General Shareholders’ Meeting acknowledges that the Board will determine the allocation and payment date of said attendance fees.

TENTH RESOLUTION

Approval of agreements referred to in article L. 225-38 et seq. of the Commercial Code

After having heard a reading of the Board of Directors' management report, and the statutory auditor’s special report regarding the agreements referred to in article L. 225-38 et seq. of the Commercial Code,

The General Shareholders’ Meeting voting under the quorum and majority conditions for ordinary general meetings,

Approves the agreements entered into or previously authorized and which remained into force during the fiscal year ended December 31, 2009, together with the transactions mentioned therein.

 
5

 
 
Translated from French
  
- RESOLUTIONS WITHIN THE COMPETENCE OF THE EXTRAORDINARY GENERAL
SHAREHOLDERS’ MEETING -

ELEVENTH RESOLUTION

Authorization to be granted to the Board of Directors for allocation of seven hundred and fifty thousand (750,000) stock options and taking note of the resulting capital increases.

The General Shareholders’ Meeting, deliberating under the conditions of quorum and majority required for Extraordinary General Meetings,

After having heard a reading of the report of the Board of Directors and of the special report of the Statutory Auditor,

In accordance with Articles L. 225-177 et seq. of the Commercial Code,

1.
  Decides to authorize the Board of Directors for a term of thirty eight months, to grant in one or several times, for the benefit of employees of the Company or of some of them, as well as for the benefit of executive officers, as referred to in Article L. 225-185 paragraph 4 of the Commercial Code, a maximum number of seven hundred and fifty thousand options giving right to the subscription for shares of the Company to be issued as capital increase of the Company.

 
2.
Decides that each option shall entitle to the subscription for one share of the Company and that the subscription price of each share by the beneficiaries of the options, which shall be determined by the Board of Directors on the date when such options are granted by the Board, will be the market price for the share, in the form of ADS, on the NASDAQ, on the day preceding the date of the meeting of the Board of Directors, provided that such price shall not be less than 80% of the average of the market price for the share on the NASDAQ, in the form of ADS, during the last twenty trading days preceding the meeting.  In this case, the price for the share shall be equal or superior to 80% of the average of the market price for the share on the NASDAQ, in the form of ADS, during the last twenty trading days preceding the meeting. The price of the shares, thus determined by the Board of Directors, may not subsequently be modified during the option period. However, in accordance with Article L. 225-181 paragraph 2 of the Commercial Code, when the Company conducts a share capital redemption or a share capital reduction, a change in the profit distribution, a free allocation of shares, an incorporation of reserve, profit, share premium to the share capital, a distribution of reserves or any issue of shares or of securities giving right to the allocation of shares with a preferential right to subscribe shares reserved to the shareholders, the Company shall take all necessary measures to protect the interests of the options beneficiaries pursuant to article L. 228-99 of the Commercial Code.

 
3.
  Decides that the options shall be exercised within a maximum ten-year term as from the date they were granted by the Board of Directors.

4.
Decides to authorize the Board of Directors and to grant it all powers in order to:

 
(i)
set the terms and conditions of grant of the options, freely determine the beneficiaries of such options, subject to the provisions of applicable laws and regulations, and, within such framework, if it considers it appropriate, set the obligation for each beneficiary to be an employee of the Company and/or of the companies referred to in Article L. 225-180-I of the Commercial Code, and/or to be an officer of the Company within the meaning of Article L. 225-185 paragraph 4 of the Commercial Code, at the time of the exercise of the options;
 
 
6

 
 
Translated from French
  
 
(ii)
set, if it considers it appropriate, a period of untransferability of the subscribed shares, in accordance with the conditions provided by applicable laws and regulations,
(iii)
set the subscription price of the shares to which the options thus granted give right, in accordance with the terms and conditions determined by the Extraordinary General Shareholders’ Meeting,
(iv)
set the exercise period(s) of the options thus granted, subject to the prohibitions and/or limitations provided by applicable laws and regulations and the by-laws in this regard, at the times that it will deem to be appropriate.

 
5.
  Decides to authorize the Board of Directors and to grant it all powers for the purpose of issuing a maximum of 750,000 shares with an approximate nominal value of 0.12196 euros, and accordingly, increasing the share capital in a maximum nominal amount of 91,470.00 euros.

 
6.
  Acknowledges that, in accordance with Article L. 225-178 paragraph 1 of the Commercial Code, the authorization thus granted to the Board of Directors entails, for the benefit of options beneficiaries, express waiver, by the shareholders, of the preferential right to subscribe for the shares that will be issued subsequently to the exercise of options.

 
7.
   Decides accordingly to authorize the Board and to grant it all powers in order to:

 
(i)
   Receive the subscriptions and related payments,
 
(ii)
   Deposit the funds in a bank account in accordance with the law,
 
(iii)
Acknowledge the number of shares issued as a consequence of the exercises of the options granted, in accordance with the provisions of Article L. 225-178 paragraph 3 of the Commercial Code, to amend the by-laws accordingly and, more generally,
 
(iv)
Take all measures necessary to implement the capital increase and complete all formalities required by law.

TWELFTH RESOLUTION

Authorization to be granted to the Board of Directors in view of allocating two hundred thousand (200,000) shares at no cost (“free shares”) and establishment of the subsequent capital increases.

The General Meeting, deliberating under the conditions of quorum and majority required for Extraordinary General Meetings,

after hearing the reading of the report by the Board of Directors and the audit report by the Statutory Auditors,

in application of Articles L. 225-197-1 et seq. of the Commercial Code:

1.
authorizes the Board of Directors to proceed, in one or several times, with the free allocation of the Company’s shares, existing or to be issued, for the benefit of the employees of the Company or the companies and the economic interest groupings which are linked to it pursuant to the conditions stipulated in Article L. 225-197-2 of the Commercial Code or for the benefit of the company managers referred to in Article L. 225-197-1, II of the Commercial Code;

 
7

 
 
Translated from French
  
2.
decides that the Board of Directors shall determine the identity of the beneficiaries, who can be employees or certain categories thereof of both the company and the companies which are bound to it directly or indirectly, pursuant to the conditions of Article L 225-197-2 of the Commercial Code and/or the company managers who meet the conditions of Article L 225-197-1 of the Commercial Code;

3.
decides that the Board of Directors shall determine the conditions and, where appropriate, the criteria for allocation of the shares;

4.
decides that the total number of shares free allocated is fixed at two hundred thousand shares (200,000), excluding adjustment of this number in order to take account of the operations necessary for preserving the rights of the beneficiary. In any event, the number of shares that can be allotted free of charge by the Board by virtue of the present delegation cannot exceed ten percent (10%) of the registered capital existing on the day of the first allocation;

5.
decides that allocation of the shares to their beneficiaries will be definitive only on expiry of a minimum acquisition period of two (2) years and that the minimum duration of the beneficiary’s obligation of conservation at the end of the acquisition period is fixed at two (2) years, the Board of Directors having the option of extending either of the time limits. Nonetheless, the shares will be definitively allocated prior to expiry of this period in the event of disability of the beneficiary corresponding to classification in the second or third of the categories provided for in Article L 341-4 of the Social Security Code;

6.
decides, in dispensation from the above, that beneficiaries who are not residents in France on the allocation date, for whom the taxable event coincides with the end of the acquisition period, will be allocated the shares definitively on expiry of a minimum acquisition period of four (4) years, except in the event of disability, as stated above. These same beneficiaries will then be bound by no period of conservation;

7.
takes due cognizance that, concerning the shares to be issued, the present decision will include, at the end of the acquisition period, a capital increase through incorporation of reserves, profits or share premiums in favor of the beneficiaries of said shares and correlative renunciation by the shareholders in favor of said beneficiaries to the part of the reserves, profits or premiums thus incorporated;

8.
fixes at thirty-eight (38) months, as from the date of the present Meeting, the duration of validity of the present authorization;

9.
delegates all powers to the Board of Directors in order to implement the present authorization within the limits fixed above and thus determine the effects on the rights of the beneficiaries of the operations modifying the capital or likely to influence the value of the shares to be allotted and realized during the periods of acquisition and conservation; where appropriate, to establish the existence of sufficient reserves and proceed, at the time of each allotment, with transfer to a non-available reserves account of the sums required for paying up the new shares to be allotted; to decide on capital increase(s) through the incorporation of reserves, premiums or profits correlative to the issuance of new shares allotted free of charge; to proceed with acquisitions of the necessary shares by means of offers of sale made to all shareholders proportionally to the number of ordinary shares held by each of them; to take all useful measures for ensuring compliance with the obligation of conservation required of the beneficiaries; and, generally, to do everything, within the scope of the regulations in force, that the implementation of the present authorization will require;

 
8

 
 
Translated from French
  
10.
takes due cognizance of the fact that, in the event that the Board of Directors should make use of this authorization, it shall inform the Ordinary General Meeting each year of the operations performed by virtue of the provisions stipulated in Articles L. 225-197-1 to L. 225-197-3 of the Commercial Court pursuant to the conditions stipulated by Article L. 225-197-4 of said Code.
 
THIRTEENTH RESOLUTION

Authorization to be granted to the Board of Directors for issue of a maximum number of two hundred and fifty thousand (250,000).stock warrants (BSA) reserved for a category of persons consisting of the company’s directors who are neither authorized agents nor employees of the company, but including the Chairman of the Board of Directors; authorization to be granted to the Board of Directors for carrying out the resulting capital increases.

The General Shareholders' Meeting, voting under the quorum and majority requirements for extraordinary general meetings, after having heard a reading of the Board of Directors' report and Statutory Auditor’s special report, acknowledging that the share capital of the Company is fully paid up,

in accordance with the provisions of Articles L. 225-138 and L. 228-91 et seq. of the Commercial Code,

1.
decides to authorize the Board to issue two hundred and fifty thousand (250,000) warrants (BSA) for a subscription price to be paid up in cash and determined by the Board based on the evaluation of an independent expert.  Such evaluation shall be the fair value of the warrants (BSA) which will be in part a function of the subscription price of the shares to be determined by the Board, in accordance with the provisions set forth in paragraph 3 below.  The subscription amount of these warrants (BSA), if any, will be registered in a special reserve account labelled "issue premium" which will carry rights for all shareholders;

2.
decides to cancel the preferential right of subscription attributed to the shareholders by Article L. 225-132 of the Commercial Code and to reserve the subscription of these two hundred and fifty thousand (250,000) warrants (BSA), to the following category of beneficiaries:  Directors of the Company who are not officers and/or employees of the Company, but including the Chairman

3.
decides that each warrant (BSA) will give its holder, subject to the terms and conditions set forth hereafter and in the Board’s decision to issue the warrants (BSA), the right to subscribe to one share of the Company for a subscription price which shall be the market price for the share, in the form of ADS, on the NASDAQ, on the closing of the trades on the day preceding the decision of the Board to issue such warrants (BSA), provided that such price shall not be less than 80% of the average of the market price for the share on the NASDAQ, in the form of ADS, during the last twenty trading days preceding such Board’s decision. In this case, the price for the share shall be equal to 80% of the average of the market price for the share on the NASDAQ, in the form of ADS, during the last twenty trading days preceding such Board’s decision;

 
9

 
 
Translated from French
  
4.
resolves that the shares thus subscribed upon exercise of the warrants (BSA) shall be fully paid up on the date of their subscription, either in cash or by offset of debt in the conditions laid down by law;

5.
decides that each warrant (BSA) shall be exercised by its holder in accordance with the conditions set forth by the Board’s decision to issue the warrants (BSA), provided that such exercise shall occur within four years from the issuance date and that the holder is still a member of the Board of Directors of the Company on the day of such exercise;

6.
If its holder fails to exercise the warrant in whole or in part at the expiry of the above mentioned period, the warrant (BSA) and the attached right to subscribe will lapse automatically;

7.
decides that, as of, at the issuance date of the warrants (BSA), the Company will be entitled to:

- conduct any change in its corporate organization,
- conduct any change in its corporate purpose,
 
- change the allocation rule of its profits and to redeem its share capital, subject to the Company taking all the necessary measures to protect the warrants holders pursuant to Article L. 228-99 of the Commercial Code,
- issue preferred shares subject to the Company taking all the necessary measures to protect the warrants holders pursuant to Article L. 228-99 of the Commercial Code;

8.
decides that, in the event the Company issues, under any circumstances, new shares with a preferential right to subscribe reserved to its shareholders, or if the Company conducts a distribution of its reserves, in cash or in kind, and of its share premiums or if the Company changes the allocation of its profits through the issuance of preferred shares, the Company will take all the necessary measures to protect the interests of the warrants’ holders pursuant to the provisions of Article L. 228-99 of the Commercial Code;

9.
decides that, in the case of a capital reduction, motivated or not by losses, and conducted through either a decrease of the par value of the shares or a decrease of the number of shares, the warrants holders’ rights will be decreased accordingly as if they had been exercised, before the date when the capital decrease has become final;

10.
acknowledges that, pursuant to the provisions of Article L. 228-103 et seq. of the Commercial Code, the warrants’ holders will all be grouped together in order to defend their common interests, in an assembly (a “masse”) with a civil personality.  General warrants holders meetings will be convened to authorize any changes in the issuance terms and conditions and to decide on any decision regarding the conditions of subscription or allocation of the shares as set forth at the time issuance took place.  Each warrant will give access to one voting right.  The conditions regarding the quorum and the majority will be those determined in the second and third paragraph of Article L. 225-96 of the Commercial Code.  The expenses incurred in connection with such meetings, as well as, generally, any expenses in connection with the assembly (“masse”) will be borne by the Company;
 
 
10

 
 
Translated from French
  
11.
Consequently and in accordance with the provisions of Article L. 228-91 of the Commercial Code, authorizes the issue of a maximum of two hundred and fifty thousand (250,000) new ordinary shares of an approximate nominal value of 0.12196 euro each to which exercise of warrants (BSA) will give rise, that is, a capital increase of an approximate maximum nominal amount of 30,490.00 Euros, without taking into account, as the case may be, any additional shares that may be issued to protect the interests of the warrants’ holders pursuant to the provisions of Article L. 228-99 of the Commercial Code;

12.
decides that the new shares remitted to the subscriber on exercise of the warrant will be subject to all the provisions of the bylaws of the Company and will carry distribution rights from the date of their creation;

13.
acknowledges that, in accordance with Article L. 225-132 paragraph 6 of the Commercial Code, the decision of the General Shareholders’ Meeting automatically entails the waiver by the shareholders of their preferential rights in respect of the shares which may be issued upon exercise of the warrants (BSA), for the benefit of the holders of the above-mentioned two hundred and fifty thousand (250,000) warrants (BSA);

14.
decides that this authorization is granted for a term of eighteen (18) months starting from the date of this General Shareholders’ Meeting;

15.
acknowledges that, such warrants (BSA) shall be issued within a maximum period of eighteen (18) months from the date of the General Meeting in accordance with Article L. 225-138 of the Commercial Code;

16.
decides to grant the Board of Directors with all necessary powers to implement this decision under the terms and conditions set by the present resolution and by law, and in particular:

- to issue and fix the subscription price of the warrants (BSA)
- to determine the beneficiaries amongst the category defined by this resolution,
- to fix the issue price of the shares to be subscribed upon exercise of the warrants (BSA) in accordance with terms and conditions set by the present resolution, the dates, periods and conditions of subscription and final details of the issue within the limits laid down by this general meeting of shareholders and to allocate the issue premium, as the case may be,
- to close the subscription period early or extend its date, if required,
- to gather the subscriptions and payments in respect of the subscription for the aforementioned warrants (BSA),
- to record the number of shares issued on exercise of the warrants (BSA) and carry out any formalities resulting from the corresponding increases in share capital and make the corresponding amendments to the bylaws,
- to take any action required to ensure the protection of the warrant holder in the event of financial operations relating to the Company, in accordance with the legal and regulatory provisions in force, and generally, to take any action and carry out any formality which is useful in respect of this issue.

FOURTEENTH RESOLUTION

Authorization to be granted to the Board of Directors for increasing the share capital by issues of shares reserved for the members of a company saving plan established in application of Articles L.3332-18 et seq. of the Labour Code.

The General Shareholders' Meeting, voting under the quorum and majority requirements for extraordinary general meetings,

After having heard a reading of the Board of Directors' report and Statutory Auditor’s special report,

 
11

 
 
Translated from French
  
Acknowledging that the share capital of the Company is fully paid up,

In accordance with the provisions of Articles L. 225-129, L. 225-129-1, L. 225-129-6 and L. 225-138-1 of the Commercial Code and Article L. 3332-18 et seq. of the Labor Code,

1.
authorizes the Board of Directors to carry out, on one or more occasions, on its own resolution, an increase of the share capital, through the issuance of shares reserved, directly or through an Employee Profit Sharing FCP (Fonds commun de placement d’entreprise”), to members of a company sponsored saving plan, as provided for in Article L. 3332-18 et seq. of the Labor Code, for employees of the Company or its affiliates, as defined under Article L. 225.180 of the Commercial Code, who shall meet additional criteria to be defined by the Board, if any (the “Group Employees”);

2.
decides to cancel, in favor of those Group Employees, the preferential subscription rights of the shareholders set forth in Article L. 225-132 of the Commercial Code, to the shares to be issued under this resolution;

3.
decides that this authorization is granted for a term of twenty-six (26) months starting from the date of this General Shareholders’ Meeting;

4.
decides to set at 1% of the share capital, as of the date of this meeting, the issuance of shares that could result from the use of this authorization;

5.
decides that the subscription price per share for the shares to be issued in accordance with this authorization shall be determined by the Board of Directors in accordance with Article L. 3332-18 of the Labor Code;

6.
decides to grant the Board of Directors with all powers necessary to implement this resolution in accordance with applicable laws and regulations, and subject to the limitations and conditions specified above;

7.
acknowledges that, in the event the Board uses this authorization, it shall so inform the next ordinary general meeting of the shareholders of the operations in accordance with applicable laws and regulations.

FIFTEENTH RESOLUTION

Powers for formalities.

The General Shareholders’ Meeting grants a power of attorney to the bearer of an original, an except or a copy hereof, in order to effect all publication, filing and other formalities required by law.

 
12

 

Translated from French

FLAMEL TECHNOLOGIES
Société Anonyme with a share capital of Euros 2,973,702
Registered Office :
Parc Club du Moulin à Vent
33, avenue du Docteur Georges Lévy
69693 VENISSIEUX (France)
  
379 001 530 R.C.S. LYON

MANAGEMENT REPORT BY THE BOARD OF DIRECTORS
TO THE ORDINARY SHAREHOLDERS MEETING
HELD ON JUNE 25, 2010

To the Shareholders,

Pursuant to French law and the Company’s Articles of Incorporation, the Board of Directors has called an Ordinary shareholders meeting to present to you the report concerning the Company’s situation and business during the financial year ending on December 31, 2009 (the “Financial Year”) and to submit the annual financial statements concerning the said Financial Year for your approval.

In addition, we propose to you that you renew the terms of the directors for the coming year.

At the said Ordinary shareholders meeting, you will hear a reading of the reports by the auditor.

The said reports, the annual financial statements as well as all documents relating thereto were made available to you at the registered office under legal and regulatory conditions.

The annual financial statements presented to you have been established in accordance with French accounting laws, principles and methods.

You will kindly note that the accounting methods used to prepare the said annual financial statements are the same as the ones used for previous financial years.

I.           The Company’s activity

The financial year ending on December 31, 2009 represented an excellent year for Flamel in so far as continuing to improve our technologies with success, which has led to interest from new partners, but also in maintaining a solid financial position.

We have worked with many of the top twenty five pharmaceutical companies in the world, and in particular on more than twenty feasibility projects.  These projects are being conducted across a wide range of indications and with both novel and already-marketed molecules.  The majority of these concern the Medusa® Technology.  One project developed with a leading pain therapy company is an application of the TriggerLock™ technology (Micropump® platform) using multiple molecules.

In June 2009 we entered into collaboration with Baxter International Inc. to create controlled release applications of blood clotting factor replacement therapies using our Medusa® technology.  In February 2009, Merck Serono, a partner since 2007, exercised its option to license the Medusa® platform for the continued development of an already-marketed therapeutic protein proprietary. In November 2009, Pfizer, who acquired Wyeth in October 2009, exercised its option to license the Medusa® technology.  In 2007, Wyeth Pharmaceuticals became a partner when we signed a license for the application of the Medusa® platform for the controlled release of an already marketed therapeutic protein.

 
1

 
Translated from French
   
These large pharmaceutical companies have the appropriate commercial and financial structure to support a commercial launch of any of the projects conducted in collaboration with Flamel, on condition we have scientific success over the course of development.

Flamel also had several important programs on which we do not currently have a partner.  An example of the potential of the Medusa platform to improve the safety and efficacy of therapeutic proteins is our formulation of Interferon-Alpha XL, a long acting formulation of Interferon-Alpha.  In December of 2009 the “Agence Nationale de Recherche sur le SIDA (AIDS) et les Hépatites Virales” (ANRS) initiated a twelve week Phase 2 study comparing two dosage forms of our IFN-alpha XL plus ribavirin versus Peg-Intron® plus ribavirin in genotype 1 hepatitis C patients.  This builds on two previous studies we conducted that demonstrated promising results of the formulation

Internal R&D projects have been redefined and several scientific collaborations are ongoing with European Universities. Other types of partnerships and collaborations are currently being investigated.

Development activities of the company were reinforced at our Pessac site.

Flamel’s financial position has been consolidated and the level of cash is sufficient to enable the investment required in Research and Development.  Flamel equally benefitted from state grants on several key R&D projects.

Production of CoregCR microparticles for GlaxoSmithKline continued at a steady rhythm.
The exclusivity period for Coreg CR ends on 20 April, 2010 and after that time it is possible that Coreg CR may experience generic competition from one or more competitors if approval is granted by the FDA. To date, only one ANDA had been submitted, URL Pharma, and it has not yet been reviewed.

Accordingly, Flamel confirms its strong position thanks to the strength of its technology, reinforced by the diversification of its revenue stream and its numerous projects conducted in partnership with top worldwide pharmaceuticals companies.

II.         Results of the financial year activity

The following results have been prepared in accordance with French accounting standards, which have been applied consistently with prior year.

1.    Income Statement

Revenues for fiscal year 2009 amount to 37.7 million euros, compared with 24.4 million euros in 2008. The 2009 revenues include 8.5 million euros in product sales, 11.6 million euros of License revenue, 9.7 million of Research revenue and 6.7 million euros in Royalties.

Payroll, including social charges, representing 41.6 % of total operating expenses, increased by 4.7 % in 2009 to 17.8 million euros, compared with 17 million euros in 2008. This is due to recruitment of research scientists to support ongoing projects, principally on the Medusa® plateform.

Operating expenses have increased compared with 2008 (+9.4%) following an increase of research activities.

 
2

 
Translated from French
  
Financial net income, standing at 244,413 euros in 2009, results mainly from financial revenue generated by investing our available cash.  The reduction in financial net income of 712,589 euros is due to the significant reduction in interest rates.

Net loss before taxes and extraordinary income in 2009 amounted to 4.8 million euros, compared with a loss of 13.7 million euros in 2008.

After accounting for an extraordinary result of 1.4 million euros and of a research tax credit amounting to 4.7 million euros, the net profit for the financial year was 1,270,699 euros compared to a net loss of (5,226,231) euros in the previous financial year.

 
2.
Balance sheet

 
Assets

Total assets amount to 68.9 million euros, including 20.4 million euros in Property, Plant and Equipment and 47.8 million euros in current assets.

Accounts receivable at the end of the financial year stood at 6 million euros.

Short-term investments totalled 24.5 million euros at the end of 2009 (to be compared with 20.2 million euros at the end of 2008), including funds invested on the money market for 20M€ and fixed term deposits for 4.5M€.

 
Liabilities

Shareholders equity, including current year results, amounts to 50.5 million euros.

Remaining liabilities amount to 18.4 million euros, including 4 million euros in accounts payable, 2.6 million euros in advances from the “French government”, 4.4 million euros in social and tax liabilities and 2.7 million euros regarding an advance received in 2008 from OSEO, a French government agency, secured against Research and Development tax credits from 2006 and 2007.

 
3.
Capital Investments

Capital investments during the financial year amounted to 1.6 million euros, mainly for the purchase of small equipment to support ongoing Research and Development activities and maintenance of facilities.

 
4.
Financing

The Company made no external financing transactions during the 2009 fiscal year.

The financial statements are subject to shareholders’ approval at the Ordinary shareholders meeting. (First resolution)

III.      Allocation of Earnings

The financial statements as presented to you show a net profit for the financial year of 1.270.699 euros.

We propose to you to allocate this entire profit of 1.270.299 € to the retained earnings account, which, following that allocation, will amount to (95.954.953) € (Second resolution).

 
3

 
Translated from French
  
 
IV.
Dividends paid for the last three financial years and the corresponding Tax Credit

We inform you, pursuant to Article 243 bis of the General Taxation Code, that no dividends were distributed during the last three financial years.

V.       Non deductible charges

During the financial year 2009 the company recorded 22.891 euros in excess depreciation that is not tax-deductible.
In the 2009 financial year the company also incurred 245.529 euros in Directors attendance fees that are not tax deductible.

VI.      Payment Terms :

The « Loi de Modernisation de l’Economie (LME) » which is applicable as of January 1, 2009, requires a reduction and harmonization of payment terms.

The new laws on maximum payment terms are required by all economic entities.

The payment terms applied by the Company were for the most part in compliance with the law and for the remainder, have been modified to be so.

Payment terms of accounts payable as at December 31, 2009 were as follows:

Accounts Payable as at December 31, 2009
 
       
Total Accounts Payable in k€ :
    944.04  
         
Non past due Accounts Payable as of December 31, 2009
 
         
Payment Date
 
Amount k€
 
< 30 days:
    155.36  
Between 31 & 60 days:
    626.73  
Between 61 jours & 90 days:
    91.37  
> 91 days:
    1.43  
         
Past Due Accounts Payable as of December 31, 2009
 
         
Date past due
 
Amount k€
 
< 30 days:
    15.61  
Between 31 & 60 days:
    4.82  
Between 61 jours & 90 days:
    0.00  
> 91 days:
    48.72  

VII.     Table of earnings for the last five financial years

Pursuant to Article R 225-102 al 2 of the French Commercial Code, you will find attached the table summarizing the company’s earnings in each of the last five financial years.
(Cf. Appendix 1)

VIII.    Progress Made – Difficulties Encountered

Expected earnings for 2009 and attained, together with the level of cash at the end of 2008 enabled Flamel to finance its activity and its development for the year ended 31 December 2009. Our success in 2009, despite the financial crisis around the world, was achieved as a result of the value we offer to our partners in addition to careful management of our costs.

The Company progressed in 2009 with the following events:
 
·
The partnered project portfolio has been maintained and reinforced, thanks to the pursuit of existing projects and the signature of new projects with both new and old partners.  This have enabled the Company to forge stronger links with existing partners and create increased interest from new partners in our technology,

 
4

 
Translated from French
  
 
·
The commencement of new internal research projects to develop our technologies to meet the growing needs of the pharmaceutical business,
 
·
The pursuit and success (two files approved) in obtaining external state funding for internal research projects,
 
·
The increase in the number of projects in human stage trials, including that with respect to IFN Alpha XL sponsored by the ANRS.
 
·
The increase in the number of scientific collaborations, notably with Universities and external consultants and experts.

The economic context has made 2009 a difficult year but the share price has progressed over the year given the solid financial position and scientific success of Flamel.

 
IX.
Goals and Prospects for the Company for 2010

Management of the company anticipates the following developments for 2010:
 
-
Pursue existing feasibility agreements and maximise the potential for as many projects as possible to be developed beyond the feasibility phase,
 
-
Pursue innovative scientific research on our Medusa® and Micropump® technologies and optimize our scientific collaborations in order to maintain our position as leader in drug delivery,
 
-
Demonstrate the execution of our internal research and development programs by increasing the numbers of patents registered, prioritizing our projects and establishing long term research projects (3 years) with partners and public financing,
 
-
Pursue a pro active Business Development approach for identifiying new partners,
 
-
Maintain a constant level of projects in preclinical phase  by signing new feasibility agreements and finalize clinical studies, in particular for IFN XL,
 
-
Pursue production of CoregCR microparticles in line with GSK demand requirements.

Future revenues, the current cash position together with strict prioritization of costs should allow the company to finance its activity and development for the current financial year. The continuation of the economic crisis could lead to a reduction by large pharmaceutical companies of their investment in research and development which could impact Flamel. However, the impact should be minimised given the success of the technology developed by Flamel and Flamel will put all in place to diversify its partnerships to remain a leader in drug delivery.

X.       The Company’s research and development activities

Our two technology platforms Medusa® and Micropump®, have been reinforced during the 2009 financial year:

Micropump® :
The feasibility agreement signed beginning of 2008, relative to our Trigger-Lock™ Technology, designed to prevent misuse of drugs subject to abuse by injection or digestion, and was pursued in 2009 on multiple molecules.
The other research and development projects both internal and with external partners are ongoing.  Two of these projects are in the clinical phase.

Medusa®:
Partnered research and development Projects on the Medusa® technology are for the large part in preclinical phase. Results obtained to date are promising.

 
5

 
Translated from French
  
XI.      Employees

As of 31 December 2009, there were 299 employees.

XII.     Capital

As of December 31, 2009, the company’s capital stood at 2,968,823,50 euros, consisting of 24,342,600 shares, as a result of two capital increases (Cf appendix 2).

 
-
The first as a result of the definitive grant as of December 11, 2009 of 117,250 shares following the grant of free shares to employees in December 2007, for 14,299.81 euros.
 
-
The second, acknowledged by the Board of Directors on March 5, 2010 for 2,439.20 euros, resulting from the issue of 20,000 shares subsequent to exercise of 20,000 stock options.

A total of 98.68% of share capital is listed on Nasdaq in the form of ADS (through the Bank of New York).

XIII.    Management of the Company and his board

The duration of the term as a company Director of Messrs Elie Vannier, Frédéric Lemoine, Lodewijk J. R. de Vink, John L. Vogelstein, Francis JT Fildes and Stephen H. Willard expire at the end of the Ordinary shareholders meeting to which you are invited, so we propose to you to renew their terms for a duration of one (1) year, namely until the Ordinary shareholders meeting to be held to approve the financial statements for the financial year ending on December 31, 2010. (Third to eighth resolution)

XIV.    Determination of the directors’ attendance fees

In view of the directors’ participation, the level of their responsibilities, we propose to you that the amount of three hundred and twenty five thousand Euros (€ 325,000) be assigned to the Board of Directors as annual attendance fees, being the same amount compared with previous fiscal year and for which the distribution and breakdown thereof will be decided by the Board of Directors. (Ninth resolution)

We also propose that the directors be allowed to acquire a maximum of two hundred and fifty thousand (250 000) autonomous stock warrants (BSA). (Thirteen resolution)

 
XV.
Mandates and functions exercised in any company, during the past financial year, by each of the company’s authorized agents

1.
Mr Elie Vannier, Chairman of the Board of directors
 
Mr Vannier is also Director of Ingénico, Famar, Conbipel and Deputy Chairman of the Supervisory Board of Groupe Loret

2.
Mr Stephen H. Willard, Chief Executive Officer
 
Mr Willard is also Chief Executive Officer of Flamel Technologies Inc and a Director of ETRADE Financial Corporation.

3.
Mr Frédéric Lemoine, Director
 
Mr Frédéric Lemoine is also Chairman of the Executive Board of Wendel and Director of Groupama, Vice-Chairman and Director of Bureau Veritas, Director of Legrand and Saint Gobain

4.
Mr John L. Vogelstein, Director
 
Mr John L. Vogelstein is also Senior Advisor of Warburg Pincus LLC and Chairman of New Providence Asset Management.  He is also Chairman of the New York City Ballet, Chairman of Prep for Prep, Vice Chairman of the Overseers Board of The Leonard N. Stern School of Business at New York University, Chairman of Third Way, Director of the Jewish Museum.

 
6

 
Translated from French
  
5.
Mr Lodewijk J. R. de Vink, Director
 
Mr Lodewijk J. R. de Vink is also Director of Alcon and Roche, member of the European Advisory Council of Rothschild, Director and member of Sotheby’s International Advisory Council.

6.
Mr Francis JT Fildes, Director
 
Mr JT Fildes is also a Director of ProStrakan Pharmaceuticals Group PLC and of Fildes Partners Ltd, and a fellow of the “Royal Society of Medecine and the Royal Society of Chemistry”.

  
XVI.
Conventions mentioned in Articles L 225-38 et seq. of the Code of Commerce

Please note that the auditor has drawn up a special report, submitted to you, indicating that certain conventions mentioned in Articles L.225-38 et seq. of the Code of Commerce were concluded or renewed during the last financial year.

We ask you to approve and/or ratify, as the case may be, any convention mentioned in Articles L.225-38 et seq. of the Code of Commerce that have been concluded or renewed during the financial year, and which might appear in the auditor’s report. (Tenth resolution)

  
XVII.
Acquisition of significant holdings in companies having their registered offices in France and acquisitions of control

Our company holds 100% of its Flamel Technologies Inc. subsidiary.

  
XVIII.
Employee shareholding, directly or by way of a company investment fund or savings plan

As of December 31, 2009, employees directly held 274,005 shares in the company, representing 1.13% of the capital.

We remind you that on December 11, 2009, your Board of Directors decided:

1)
To acknowledge issuance of 122,250 shares to 103 beneficiaries as a result of the definitive grant subsequent to the grant made by the Board on December 11, 2007 on the basis of a delegation of power that you granted on October 24, 2005 and May 15, 2007. The share capital was effectively increased by 117 150 shares, since the acquisition period of 5 000 of the 122 250 shares is four years because the free shares were granted to non French tax resident employee.

2)
To grant 295,000 free shares to the company’s employees, on the basis of a delegation of power that you granted on May 15, 2007, June 3, 2008 and June 24, 2009. The conditions for allocating the said free shares provide:

 
a.
Regarding French resident beneficiaries: The acquisition period, meaning the period at the end of which the shares shall be definitively allocated to the beneficiary, is two years starting from the allocation date, subject to the respect of an attendance condition at the end of this two years period. At the time of their definitive allocation the shares must be held for a further two years period at the end of which they may be transferred without limitation except with respect to transaction windows.

 
7

 
Translated from French
  
 
b.
Regarding non French resident beneficiaries: The acquisition period, meaning the period at the end of which the shares shall be definitively allocated to the beneficiary, is four years starting from the allocation date, subject to the beneficiary still being an employee at the end of a two years period after allocation date. At the time of their definitive allocation, the shares may be transferred without limitation except the respect of transaction windows.

XIX.
Important events occurring between the end of the financial year and the date of the present report

No major event has occurred between January 1, 2010 and the date of this report which would have a material impact on the annual accounts for the 2009 fiscal year.

Nevertheless, we remind you that the Board of Directors acknowledged:
 
-
a share capital increase of 2,439.20 Euros on March 5, 2010 as a result of the exercise of 20,000 stock options, thus bringing share capital to 2,968,823.50 Euros (see XIII).
 
-
on May 4, 2010, the effective grant of 40 000 free shares granted on April 3 ; 2008 and thus a share capital increase of 4 878.40 Euros bringing the share capital to 2 973 702 Euros comprised, of 24 382 600 shares with a nominal value of 0.12196 Euros.

The Board invites you after reading the reports by the auditor, to discuss these matters and vote on the resolutions submitted to you.

On behalf of the Board of Directors

 
8

 
  
Translated from French
  
APPENDIX 1

TABLE OF EARNINGS FOR THE LAST FIVE FINANCIAL YEARS
 

FLAMEL TECHNOLOGIES - December 31, 2009
 

   
FINANCIAL RESULTS OF LAST FIVE YEARS
  

   
Montant en euros

 
   
31/12/2005
 
31/12/2006
 
31/12/2007
 
31/12/2008
 
31/12/2009
 
                       
a) Share Capital
    2 891 118,91     2 925 755,11     2 933 194,62     2 951 947,15     2 968 823,50  
b) Number of Ordinary Shares
    23 706 590     23 990 590     24 051 590     24 205 350     24 342 600  
c) Number of Preference Shares
                               
d) Maximum number of shares to be issued by :
- Bond Issue
- Exercise of Stock Options and Warrants and issue of Free Shares
    3 465 000     4 013 250     3 947 800     3 725 357     4 341 840  
SHARE CAPITAL
                               
                                 
a) Revenues
    17 454 801,51     18 688 260,16     31 260 019,88     23 781 681,19     36 521 247,22  
b) Income before taxes, depreciation and provisions
    -17 533 232,12     -17 441 621,37     -13 370 141,82     -7 378 250,04     1 218 053,54  
c) Income Tax (Tax Credit)
    -3 371 868,76     -1 687 151,21     -1 699 714,96     -4 663 240,07     -4 742 258,00  
d) Employee's Profit-Sharing
                               
e) Income after taxes, profit sharing, depreciation and provisions
    -20 705 794,41     -17 259 531,76     -17 494 103,08     -5 226 231,48     1 270 699,14  
f) Profit Distribution
                               
ANNUAL OPERATIONS AND EARNINGS
                               
                                 
a) Income after tax and profit sharing and before depreciation and provisions
    -0,60     -0,66     -0,49     -0,11     0,24  
b) Income after tax, profit-sharing, depreciation and provisions
    -0,87     -0,72     -0,73     -0,22     0,05  
c) Dividend per share
                               
EARNINGS PER SHARE
                               
                                 
a) Average number of employees
    254     302     331     285     299  
b) Payroll Costs
    10 168 449,22     11 368 518,68     13 100 279,60     11 678 122,25     12 155 475,20  
c) Social tax costs
    4 360 234,12     6 321 735,63     5 892 622,28     5 278 445,72     5 634 990,17  
PERSONNEL COSTS
                               

 
9

 
  
Translated from French
  
APPENDIX 2

REPORT CONCERNING DELEGATIONS MADE TO THE BOARD

AUTHORIZATION GRANTED BY AN
EXTRAORDINARY SHAREHOLDERS MEETING
TO THE BOARD
 
IMPLEMENTATION BY THE BOARD
Date
 
Nature
 
Date
 
Nature
 
Share capital
increase
 
Approval by
Board of
Directors
May 10, 1996
 
Stock-options « plan 96 »
1.000.000 securities
Capital increase of € 121.959
               
Nov 20, 2000
 
Stock-option « plan 2000 »
1.000.000 titres
Augmentation du capital de € 121.959
 
April 24, 2009
 
Exercised options 20 000
 
2,439.20€
 
March 5, 2010
Dec 19, 2001
 
Stock-options « plan 2001 »
750.000 securities
Capital increase of € 91.469
               
Feb 18, 2003
 
Stock-options« plan 2003 »
1.000.000 securities
Capital increase of € 121.959
               
Nov 7, 2003
 
Stock-options« plan 2004 »
1.000.000 securities
Capital increase of € 121.960
               
March 4, 2005
 
Issue of  40 000 warrants
Capital increase of  € 4.878
Stock-options “plan 2005”
1.500.000 securities
Capital increase of € 182.940
               
Oct 24,  2005
 
Issue of 250.000 bons de souscription
Capital increase of  € 30.490
200.000 free shares
Capital increase of € 24.392
               
June 12, 2006
 
Issue of 150.000 warrants
Capital increase of € 18.294
               
May 15, 2007
 
500. 000 stocks-options
Capital increase of € 60.980
200.000 free shares
Capital increase of € 24. 392
Issue of 150.000 warrants
Capital increase of € 18.294
 
Dec 11, 2009
 
Effective
allocation of
122,250 free
shares
 
14,299.81€
(117 250
shares)
 
Dec 11, 2009
June 3, 2008
 
200.000 free shares
Capital increase of € 24.392
Issue of 250.000 warrants
Capital increase of €30. 490
               
June 24, 2009
 
200.000 free shares
Capital increase of € 24.392
Issue of 250.000 warrants
Capital increase of €30. 490
               

 
10

 

Translated from French

FLAMEL TECHNOLOGIES
Société Anonyme with a stated capital of 2,973,702 euros
Registered Office:
Parc Club du Moulin à Vent
33, avenue du Docteur Georges Lévy
69693 VENISSIEUX – France
  
379 001 530 R.C.S. LYON
 

REPORT BY THE BOARD OF DIRECTORS TO THE COMBINED SHAREHOLDERS
MEETING HELD ON  JUNE 25, 2010

Ladies and Gentlemen:

We have called you to meet in the form of a shareholders meeting in order to submit the following questions to you for your approval as extraordinary matters:

 
1.
a project for installation of a new stock option plan bearing on seven hundred and fifty thousand (750,000) shares,

 
2.
a project for installation of a new plan for a free allocation of shares bearing on two hundred thousand (200,000) shares,

 
3.
a project for issue of a total of two hundred and fifty thousand (250,000) securities offering access to the capital, taking the form of autonomous stock warrants (BSA) reserved for the company’s directors who are neither authorized agents nor employees of the company, but including the Chairman of the Board of Directors,

 
4.
a project for a capital increase reserved for the employees.

Before informing you of the details about these operations, we would like to remind you that you will find all information relative to the important events of the year 2009 for Flamel and to the figures for the financial year ending on December 31, 2009 in your Board’s management report.

1. Project for installation of a new stock option plan bearing on seven hundred and fifty thousand (750,000) shares (eleventh resolution)

To enable the Company to attract and/or keep talented senior managers and employees, and insofar as the number of stock options that your Board was authorized to allocate in connection with the previous plans is almost exhausted, we propose to you to delegate an option to the Board of Directors, for a duration of thirty-eight months, to grant, all at once or in instalments, pursuant to Articles L. 225-177 et seq. of the Code of Commerce, to the benefit of the Company’s employees or some such employees, as well as to the benefit of the senior authorized agents, as mentioned in Article L. 225-185 paragraph 4 of the Code of Commerce, a maximum of seven hundred and fifty thousand (750,000) options granting a right to subscription to the Company’s shares to be issued as a capital increase of the Company.

Each option could create a right to subscription to one Company share, the subscription price of which, for the beneficiaries of the options, could be determined by the Board of Directors on the day on which it grants the options.

 
1

 

Translated from French

We remind you in this connection that the Company’s securities, even though listed in the form of ADS (American Depositary Shares) on the NASDAQ, are all the same, in the light of French law, considered as listed for trading on a regulated market. Hence the subscription price for each share must be determined in accordance with the objective methods adopted in connection with valuation of the shares, as provided for in Article L. 225-177, paragraph 4 of the Code of Commerce, on the basis of appropriate weighting of the network, of the profitability and of the activity prospects of the business.

It appears in this connection that the most objective valuation method and that most appropriate to the Company’s case is its trading price on the NASDAQ. The fact is that the price of the share, if calculated as a function of its mathematical value and/or of the net worth, the profitability and the prospects of the Company’s activity, even if weighted, could result, in the light of the history of the share price, in the form of ADS, on the NASDAQ, in a valuation substantially below the actual economic value of the share, the trading price of which on the NASDAQ remains the most objective valuation method.

Hence we propose to you that the price of the share to which each option would create a right could be valued by the Board of Directors in accordance with the trading price of the share, in the form of ADS on the NASDAQ, on the day prior to the date of the meeting of the Board of Directors, but only condition that the said price is no less than 80% of the average trading price of the share on the NASDAQ, in the form of ADS, during the last twenty trading sessions prior to the said meeting. In such a case, the price of the share should be equal to or greater than 80% of the average trading price of the share on the NASDAQ, in the form of ADS, during the last twenty sessions preceding the said meeting. The said minimum price is the one applicable to companies whose securities are listed for trading on a regulated market.

As provided for by law, the price of the shares, determined in this way by the Board of Directors, could not then be modified for the entire duration of the option, unless, pursuant to Article L. 225-181, paragraph 2, of the Code of Commerce, when the Company carries out a redemption or reduction of the capital, a modification of the distribution of profits, a free allocation of shares, an incorporation into the capital of reserves, profits or premiums on shares, a distribution of reserves or any issue of capital securities or of other securities creating a right to allocation of capital securities including an application right reserved for the shareholders, it will have to take the steps required for protection of the interests of the beneficiaries of the options under the conditions laid down in Article L. 228-99 of the Code of Commerce.

The options should be exercised within a maximum period of 10 years starting from the date of their award to the beneficiaries by the Board of Directors.

Hence we propose to you that you should authorize the Board of Directors and entrust it with full powers for the following purposes:

 
-
determine the conditions and procedures for allocation of the options, freely determine the beneficiaries of the said options subject to the legal and regulatory provisions and, in that connection, lay down, if it considers this appropriate, an obligation for each beneficiary to be a paid employee of the Company and/or the companies mentioned in Article L. 225-180 – I of the Code of Commerce, and/or being a senior manager of the Company in the meaning of Article L. 225-185, paragraph 4, of the Code of Commerce, at the time of exercise of the options,

 
2

 

Translated from French

 
-
determine, if it considers this appropriate, a period of non-transferability of the shares acquired, under the conditions laid down in law and in the rules and regulations in effect,

 
-
determine the subscription price of the shares to which the options as granted in this way create a right, under the conditions and pursuant to the procedures laid by the Extraordinary shareholders meeting, and,

 
-
determine the period or periods for exercise of the options granted in this way, subject to the prohibitions and/or limitations provided for by law and in the rules and regulations in effect and by the Articles of incorporation in this connection, at the times it considers appropriate.

As a result of the foregoing authorization, we also propose to you that you should authorize the Board of Directors and grant it full powers for the purposes of issuing a maximum of 750,000 shares with a par value of about 0.12196 euros, and hence to increase the capital by a maximum nominal amount of 91,470 euros.

Pursuant to Article L. 225-178, paragraph 1, of the Code of Commerce, the authorization that would be granted in this way to the Board of Directors would include, to the benefit of the beneficiaries of the options, an explicit waiver by the shareholders of their preferential right to subscribe to the shares to be issued as the options are exercised.

Finally, we propose that you should authorize the Board and fully empower to do the following:

 
(i)
Receive the applications and the corresponding payments,
 
(ii)
Deposit the funds in a bank account pursuant to law,
 
(iii)
Record the number of shares issued as a result of the exercises of the options granted, pursuant to the provisions of Article L. 225-178, paragraph 3, of the Code of Commerce, and to modify the Articles of incorporation as a result, and more generally
 
(iv)
To take any appropriate steps to put through the capital increase and to carry out all formalities required by law.

2. A project for installation of a new plan for a free allocation of shares to the benefit of the members of the salaried staff and/or of certain authorized agents (Article L.225-197-1 of the Code of Commerce) (twelfth resolution)

We propose that you should delegate the option to the Board of Directors, for a duration of 38 months, to proceed, within the framework of Article L.225-197-1 of the Code of Commerce, with a free allocation of new shares resulting from a capital increase by incorporation of reserves, premiums on shares or profits.

The beneficiaries of the said allocations could be:

 
-
The members of the salaried staff or certain categories among them, both of the Company and of the companies connected with it directly or indirectly, under the conditions Article L 225-197-2 of the Code of Commerce;
 
-
The authorized agents meeting the conditions set forth in Article L 225-197-1 of the Code of Commerce.

We propose that you authorize the Board of Directors to allocate, without charge, two hundred thousand (200,000) shares at the most.

 
3

 

Translated from French

The allocation of the shares to the French resident beneficiaries will be definitive only at the end of an acquisition period having a minimum duration of two (2) years starting with the Board’s decision to allocate the shares. However, the shares will be definitively allocated before the end of the said period in case of disability of the beneficiary corresponding to classification in the second or the third of the categories provided for in Article L341-4 of the Social Security Code.

Furthermore, the French resident beneficiaries shall have to keep the shares allocated for a minimum duration of two years starting with the time of their definitive allocation. As an exception, the shares allocated shall be freely transferable in case of a request for award filed by the heirs of a deceased beneficiary or in case of disability of the beneficiary corresponding to their classification in the above-mentioned categories of the Social Security Code.

As a departure from the foregoing, the beneficiaries who are not French residents on the date of allocation for whom the generating fact of taxation coincides with the end of the period of acquisition shall definitively receive the shares at the end of a minimum acquisition period of four years, except in case of disability, as mentioned above. Those same beneficiaries shall not then be required to observe any period for keeping the shares.

The Board of Directors shall have the option of increasing the duration of the said minimum acquisition and preservation periods.

Within the limits set above, the Board shall hold full powers for determine the conditions and, if the case arises, the criteria for allocation of the shares, determine the identity of the beneficiaries of the free allocations from among the persons complying with the conditions set above, as well as the number of shares due to each of them, determine the effects on the beneficiaries’ rights of the operations modifying the capital or which might influence the value of the shares to be allocated and carried out during the periods of acquisition and of preservation, if the case arises, record the existence of sufficient reserves and carry out, at the time of each allocation, the transfer to an account of frozen reserves of the amounts required for paying up the new shares to be awarded, decide on the capital increase or increases by incorporation of reserves, premiums on shares or profits, related to the issue of the new shares allocated without charge, carry out the required acquisitions of shares by means of sale offers made to all shareholders in proportion to the number of ordinary shares held by each of them, take all useful steps to guarantee respect for the preservation obligation incumbent on the beneficiaries, and generally do, within the framework of the rules and regulations in effect, everything made necessary by implementation of the present authorization.

The present authorization shall entail, by right, a waiver by the shareholders of their preferential application right to the new shares issued by incorporation of reserves, premiums on shares and profits.

3. Project for issue of a total of two hundred and fifty thousand (250,000) Autonomous Stock warrants (BSA) reserved for the category of persons consisting of the company’s directors who are neither authorized agents nor employees of the company, but including the Chairman of the Board of Directors.(thirteenth resolution)

During the present meeting, we will put a proposal to you for renewing the mandates of Messrs. Elie Vannier (Chairman of the Board of Directors), Frédéric Lemoine, Lodewijk J. R. De Vink, John L. Vogelstein and Francis JT Fildes (Directors who are not employee).

 
4

 

Translated from French

The Company believes the profit-sharing in the form of shares is the most effective way of having the interests of the directors and of the employees converge, and of keeping key staff.

Hence, and in the light of their important contribution to Company management, we propose to you to authorize issue of a maximum of two hundred and fifty thousand (250,000) stock warrants (BSA)

In order to give the Board the greatest possible flexibility, we propose that you authorize the Board to use the said authorization for a period of eighteen (18) months, and to delegate the powers to the Board for determining the beneficiaries of the stock warrants (BSA) and the subscription price of the said stock warrants (BSA) in the light of their fair value.

This decision to issue stock warrants (BSA) presupposes, if you decide to adopt it, elimination of the shareholders’ preferential application rights to the stock warrants (BSA), in order to reserve subscription thereto for their beneficiaries.

We inform you that with respect to the said two hundred and fifty thousand (250,000) stock warrants (BSA), you will have to suppress the shareholders’ preferential application right appearing in Article L. 225-132 of the Code of Commerce, and reserve applications for a category of persons consisting of the Company’s directors who are neither authorized agents nor Company employees, but including the Chairman of the Board of Directors.

We propose to you that you authorize the Board of Directors to issue a maximum of two hundred and fifty thousand (250,000) stock warrants (BSA) for a subscription price having to be paid up in full at the time of subscription by cash payments, and set by the Board of Directors on the basis of a valuation made by an independent expert. The said valuation shall have to correspond to the fair value of the stock warrants (BSA), and in particular shall include the subscription price of the shares as determined by the Board of Directors in accordance with the provisions in the following paragraph.

We propose to you to decide that an stock warrant (BSA) shall give its holder, subject to the terms and conditions defined below and by the decision of the Board of Directors relative to the issue of the stock warrants (BSA), the right to subscribe to one (1) Company share, at a subscription price to be determined by the Board of Directors with reference to the trading price of the share, in the form of ADS, on the NASDAQ, at the close of that market on the day preceding the decision by the Board of Directors relative to the issue of the stock warrants, but only as long as the said price is no less than 80% of the average trading prices of the share on the NASDAQ, in the form of ADS, during the last twenty trading sessions prior to the said decision; in that case, the price of the share shall have to be equal to 80% of the average trading prices of the share on the NASDAQ, in the form of ADS, during the last twenty sessions preceding the decision by the Board of Directors relative to issue of the stock warrants.

We propose that you decide that each stock warrant (BSA) may be exercised by its holder subject to the terms and conditions defined below and decided on by a decision made by the Board on the occasion of the issue of the stock warrants (BSA), and at the latest within five years following their issue, and only as long as the said holder is a member of the Board of Directors on the day of the said exercise.

We propose that you decide that starting with the time of issue of the stock warrants (BSA), the Company shall be entitled to do the following:
 
 
-
modify its form,
  
 
5

 

Translated from French
    
 
-
modify its business purpose,
 
-
modify the rules regarding the distribution of its profits, redeem its capital, subject to taking the steps required for maintaining the rights of the holders of the stock warrants (BSA) under the conditions laid down in Article L. 228-99 of the Code commerce,
 
-
create preferred shares, subject to taking the steps required for maintaining the rights of the holders of the stock warrants (BSA) under the conditions laid down in Article L. 228-99 of the Code of Commerce.

We propose that you decide that if the Company decides to issue securities including a preferential application right for the shareholders, to increase its capital by incorporation of reserves, profits or premiums on shares, or to distributes reserves in cash or in portfolio securities, or decides to modify the distribution of its profits by issuing preferred shares, the Company shall take the required steps for maintaining the rights of the holders of stock warrants (BSA) under the conditions defined in Article L. 228-99 of the Code of Commerce.

We propose that you decide that in case of a reduction of its capital, whether or not that is due to losses, and carried out by reducing the par value or the number of securities constituting the capital, the rights of the holders of the stock warrants (BSA) shall be reduced as a result, as if they had exercised them before the date on which the capital reduction has become final.

We propose that you take note, pursuant to the provisions of Article L. 228-103 et seq. of the Code of Commerce, that the holders of the stock warrants (BSA) are grouped by right, for defence of their common interests, into a whole enjoying legal personality. The general meetings of the holders of the stock warrants (BSA) are called to authorize any modification of the issue contract and to rule on any decision affecting the conditions regarding subscription to or allocation of capital securities determined at the time of the issue. Each stock warrants (BSA) creates a right to one vote. The quorum and majority conditions are the ones established in the second and third paragraphs of Article L. 225-96 of the Code of Commerce. The meeting expenses as well as, in a general way, all expenses relating to the functioning of the whole are for the Company’s account.

We propose that you decide on issue of a maximum number of 250,000 Company shares with a par value of 0.12196 euros each, to which exercise of the stock warrants (BSA) issued will create a right, namely a capital increase in a maximum nominal amount of 30,490 Euros, to which one must add, if the case arises, a number of additional shares to be issued to safeguard the rights of the holders of the stock warrants (BSA) under the conditions defined in Article L. 228-99 of the Code of Commerce.

We propose that you decide that the new shares delivered to the subscriber at the time of exercise of its stock warrants (BSA) shall be subject to all of the provisions of the Articles of incorporation, and shall bear dividend rights as of the time of their issue.

We propose that you set the duration of validity of the present authorization at eighteen (18) months, starting with the date of the present meeting.

We propose that you take note, pursuant to the provisions of Article L. 225-138 of the Code of Commerce, of the fact that the issue of the stock warrants (BSA) shall have to be carried out within a period of eighteen (18) months, starting with the date of the present meeting

Finally, we propose that you decide to grant full powers to the Board of Directors to implement the present authorization, pursuant to the provisions and within the limits to be laid down in your resolution, and in particular for the following purposes:

 
6

 

Translated from French

 
-
issue the stock warrants (BSA) and determine their subscription price,
 
-
close out the list of the beneficiaries within the defined category of persons,
 
-
determine the subscription price of the shares to be issued upon exercise of the stock warrants (BSA), subject to the terms and conditions laid down in your resolution, the opening and closing dates of the subscriptions, and the definitive conditions of the said issue, and enter the premium on shares, if any,
 
-
order early closing of the subscription or extend it, depending on the case,
 
-
gather the subscriptions to the stock warrants (BSA) and the payments relating thereto,
 
-
record the number of shares issued due to exercise of the stock warrants (BSA), carry out the formalities resulting from the corresponding capital increases and make the related modifications of the Articles of incorporation,
 
-
take any steps to ensure protection of the holders of stock warrants (BSA) in case of a financial operation concerning the Company, this pursuant to the legal and regulatory provisions in effect, and
 
-
in a general way, take all steps and carry out all formalities that are useful in connection with the present issue.

4. Proposal to authorize the Board to increase the share capital by issue of shares reserved for the employees (Fourteenth resolution)

Pursuant to the provisions of Article L. 225-126-6 of the Code of Commerce and of Article L. 3332-18 of the Labour Code, we remind you that the shareholders must make a decision on a draft resolution aimed at carrying out a capital increase under the conditions laid down in Article L. 3332-18 of the Labour Code (reserved, directly or through the intermediary of a company investment fund, for the members of a company savings plan, even in the absence of such a plan within the Company), on the occasion of each capital increase by cash conveyance that is proposed to them.

As a result of the operations regarding a capital increase listed above, we therefore invite you to make a decision on the proposed capital increase reserved for the Company’s employees.

Such a resolution implies the suppression of the preferential application right granted to the shareholders, to the holders of stock warrants and to any other holder of securities offering access to the Company’s capital, pursuant to the applicable legal and regulatory provisions.

In order to comply with this legal requirement, we are submitting for your approval a draft resolution authorizing the Board of Directors and delegating to it, for a period of twenty-six months, the powers required for increase in the share capital, in a nominal amount equal at most to 1% of the share capital on the date of the present meeting, to set the issue price under the conditions laid down in the provisions of Article L. 3332-18 of the Labour Code, subject to supervision by the Auditor, and to determine the number of shares allocated to each beneficiary pursuant to the provisions of Article L. 225-138 of the Code of Commerce.

We draw your attention to the fact that the Company does not have a company savings plan.

 
7

 

Translated from French

Furthermore, the Board of Directors considers that the present authorization is unnecessary in view of the Company’s situation and other existing compensation tools. Hence we invite you to vote against this resolution.

5. Powers for formalities (Fifteenth resolution)

The fifteenth resolution is a usual one granting the required powers for carrying out the notice and other formalities to be required in the light of the nature of the present combined Shareholders meeting of an ordinary and extraordinary nature.

* * *

In the light of the draft resolutions subject to the jurisdiction of the Ordinary Shareholders' Meeting (first to tenth resolution), which you will find described in the management report submitted by your Board of Directors, we advise the shareholders to vote in favour of these resolutions.

Furthermore, and in the light of the draft resolutions subject to the jurisdiction of the Extraordinary Shareholders meeting (eleventh to fifteenth resolution), we advise the shareholders to vote in favour of the eleventh, twelfth, thirteenth and fifteenth resolutions, and to vote against the fourteenth resolution.

The Board of Directors

 
8

 
Unassociated Document
Document unique de vote par correspondance ou procuration
Form of proxy and vote by mail

+IMPORTANT : avant d’exercer votre choix, veuillez prendre connaissance des instructions situées au verso / Before selecting, please see instructions on reverse side
 
QUELLE QUE SOIT L’OPTION CHOISIE, DATER ET SIGNER AU BAS DU FORMULAIRE / WHICHEVER OPTION IS USED, DATE AND SIGN AT THE BOTTOM OF THE FORM
 
   A ú Je désire assister à cette assemblée et demande une carte d’admission : dater et signer au bas du formulaire / I wish to attend the shareholders’ meeting and request an admission card : date and sign at the bottom of the form.
   B ú J’utilise le formulaire de vote par correspondance ou par procuration ci-dessous, selon l’une des 3 possibilités offertes / I prefer to use the postal voting form or the proxy form as specified below.
   FLAMEL TECHNOLOGIES
 
   Société Anonyme au capital de 2.973.702  €
   Siège social : Parc Club du Moulin à Vent
   33, avenue du Docteur Georges Lévy
   69693 VENISSIEUX – France
   379 001 530 R.C.S. LYON
ASSEMBLEE GENERALE MIXTE
ORDINAIRE ET EXTRAORDINAIRE
du 25 juin 2010  (à 11 heures au siège social) sur 1ère convocation ou
du 2 juillet 2010 sur deuxième convocation
 
COMBINED ORDINARY AND EXTRAORDINARY
GENERAL MEETING
of June 25, 2010 (at 11.00 am. at the registered office)(1st calling) or July 2nd, 2010 (2nd calling)
 CADRE RESERVE / For Company’s use only
  
 
Identifiant / Account< /font>
  
Nombre d’actions / Number of shares
 
Nombre de voix / Number of voting rights
     
   ú JE VOTE PAR CORRESPONDANCE / I VOTE BY POST
Cf. au verso renvoi (3) -- See reverse (3)
ú JE DONNE POUVOIR AU PRESIDENT DE
L’ASSEMBLEE GENERALE
 
Date et signer au bas du formulaire sans
rien remplir
 
I HEREBY GIVE MY PROXY TO THE
CHAIRMAN OF THE MEETING
Date and sign the bottom of the form without
completing it
Cf. au verso renvoi (2) – See reverse (2)
ú  JE DONNE POUVOIR A :
(soit le conjoint, soit un autre actionnaire – cf. renvoi (2) au verso – pour me représenter à l’assemblée
/ I HEREBY APPOINT (you may give your PROXY either to your spouse or to another shareholder – see reverse (2) -- to represent me at the above-mentioned meeting.
 
M., Mme ou Mlle / Mr., Mrs. or Miss :
__________________________________________
Adresse/Address :____________________________
_______________________________________
Je vote OUI à tous les projets de résolutions présentés ou agréés
par le Conseil d’administration, à l’EXCEPTION de ceux que je
signale en noircissant comme ceci n la case correspondante et
pour lesquels je vote NON ou je m’abstiens.
 
I vote FOR all the draft resolutions presented or approved by the
Board of Directors EXCEPT those indicated by a shaded box – like
this n for which I vote against or abstain.
Sur les projets de résolutions non approuvés ou non agréés par
le Conseil d’administration, je vote en noircissant comme ceci
n la case correspondante à mon choix.
 
On the draft resolutions not approved by the Board of
Directors, I cast my vote by shading the box of my choice –
like thisn.
 1           2                 3            4           5
 
 o o o o o
6           7                 8            9           10
 
 o  o o o     o
 
11        12               13            15
 
 o   o o   
 
Oui/                  Non/No
Yes                  Abst/Abs
 
 
14     o         o
 
Nom, Prénom, Adresse de l’actionnaire (si ces informations figurent déjà, les vérifier et les rectifier éventuellement)
  
/ Surname, first name, address of the shareholder (if this information is already supplied, please verify and correct if necessary)
Cf. au verso renvoi (1) – See reverse (1)
__________________________________________________________________________
_________________________________________________________________________
Si des amendements ou des résolutions nouvelles étaient présentés en assemblée / If amendments or new resolutions are presented during the meeting :
 
– Je donne pouvoir au Président de l’A.G. de voter en mon nom / I appoint the Chairman of the meeting to vote on my behalf ……………………………………………………………………………………………………………….………¨
 
– Je m’abstiens (l’abstention équivaut à un vote contre) / I abstain from voting (is equivalent to a vote against …………………………………………………………………………………………………………….………...¨
 
– Je donne procuration (cf. au verso renvoi (2)) à M., Mme ou Melle _________________________________ pour voter en mon nom / I appoint (see reverse (2)) Mr., Mrs. or Miss / to vote on my behalf. ………………………………………………………..¨
 
 
Date et signature :
 
_______________________________________________________
Pour être prise en considération, toute formule doit parvenir au plus tard :
in order to be considereed, this completed form must be returned at the latest :
Sur 1ère convocation / on 1st notification AGO- AGE / ordinary meeting / extraordinary meeting
Sur 2ème convocation / on 2nd notification AGO- AGE
 /ordinary meeting / extraordinary meeting
 
29 juin 2010 /June 29, 2010
A la SOCIETE / to the Company
22 juin 2010 / June 22, 2010

 

 

UTILISATION DU DOCUMENT
 
  A.      L’actionnaire désire assister personnellement à l’assemblée. Dans ce cas, il doit, au recto du document, cocher la case A puis dater et signer au bas du formulaire.
  B.      A défaut, l’actionnaire peut utiliser le formulaire de vote (*). Dans ce cas, il doit, au recto du document, cocher la case B et choisir l’une des trois possibilités :
— Voter par correspondance (cocher la case appropriée, puis dater et signer au bas du formulaire)
— Donner pouvoir au Président de l’Assemblée Générale (dater et signer au bas du formulaire sans remplir)
— Donner pouvoir à une personne dénommée (cocher et compléter la case appropriée, puis dater et signer au bas du formulaire)
 
QUELLE QUE SOIT L’OPTION CHOISIE la signature de l’actionnaire est indispensable
(1) Le signataire est prié d’inscrire très exactement, dans la zone réservée à cet effet, ses nom (en majuscules d’imprimerie), prénom usuel et adresse ; si ces indications figurent déjà sur le formulaire, il est demandé au signataire de les vérifier et, éventuellement, de les rectifier.
Pour les personnes morales, indiquer les nom, prénom et qualité du signataire.
Si le signataire n’est pas lui-même un actionnaire (exemple : Administrateur légal, Tuteur, etc.) il doit mentionner ses nom, prénom et la qualité en laquelle il signe le formulaire de vote.
Le formulaire adressé pour une Assemblée vaut pour les autres Assemblées successives convoquées avec le même ordre du jour (Art. R 225.77 §3 du Code de Commerce ).
VOTE PAR CORRESPONDANCE
(3) Art. L 225-107 du Code de Commerce (extrait) :
« Tout actionnaire peut voter par correspondance, au moyen d’un formulaire dont les mentions sont fixées par décret. Les dispositions contraires des statuts sont réputées non écrites.
Pour le calcul du quorum, il n’est tenu compte que des formulaires qui ont été reçus par la Société avant la réunion de l’Assemblée, dans les conditions de délais fixés par décret. Les formulaires ne donnant aucun sens de vote ou exprimant une abstention sont considérés comme des votes négatifs. »
 
Si vous désirez voter par correspondance, vous devez obligatoirement cocher la case JE VOTE PAR CORRESPONDANCE au recto.
Dans ce cas, il vous est demandé :
Pour les projets de résolutions proposées ou agréés par le Conseil d’Administration ou le Directoire ou la Gérance :
- soit de voter « oui » pour l’ensemble des résolutions en ne noircissant aucune case,
- soit de voter « non » ou de vous « abstenir » (ce qui équivaut à voter « non ») sur certaines ou sur toutes les résolutions en noircissant individuellement les cases correspondantes.
Pour les projets de résolutions non agréés par le Conseil d’Administration ou le Directoire ou la Gérance :
- de voter résolution par résolution en noircissant la case correspondant à votre choix,
En outre, pour le cas où des amendements aux résolutions présentées ou des résolutions nouvelles seraient déposées lors de l’assemblée, il vous est demandé d’opter entre 3 solutions (pouvoir au Président de l’Assemblée Générale, abstention ou pouvoir à personne dénommée), en noircissant la case correspondante à votre choix.
POUVOIR AU PRESIDENT DE L’ASSEMBLEE GENERALE OU POUVOIR A UNE PERSONNE DENOMMEE
(2) Art. L 225-106 du Code de Commerce (extrait) :
« Un actionnaire peut se faire représenter par un autre actionnaire ou par son conjoint. »
 
Tout actionnaire peut recevoir les pouvoirs émis par d’autres actionnaires en vue d’être représenté à une Assemblée, sans autres limites que celles résultant des dispositions légales ou statutaires fixant le nombre maximal des voix dont peut disposer une même personne tant en son nom personnel que comme mandataire. Avant chaque réunion de l’Assemblée Générale des actionnaires, le Président du Conseil d’Administration ou le Directoire, selon le cas, peut organiser la consultation des actionnaires mentionnés à l’article L. 225-102 afin de leur permettre de désigner un ou plusieurs mandataires pour les représenter à l’Assemblée Générale conformément aux dispositions du présent article. Cette consultation est obligatoire lorsque, les statuts ayant été modifiés en application de l’article L. 225-23 ou de l’article L. 225-71, l’Assemblée Générale ordinaire doit nommer au Conseil d’Administration ou au Conseil de surveillance, selon le cas, un ou des salariés actionnaires ou membres des Conseils de surveillance des fonds communs de placement d’entreprise détenant des actions de la société.
Les clauses contraires aux dispositions des alinéas précédents sont réputées non écrites.
Pour toute procuration d’un actionnaire sans indication de mandataire, le Président de l’Assemblée Générale émet un vote favorable à l’adoption de projets de résolutions présentés ou agréés par le Conseil d’Administration ou le Directoire, selon le cas, et un vote défavorable à l’adoption de tous les autres projets de résolution. Pour émettre tout autre vote, l’actionnaire doit faire choix d’un mandataire qui accepte de voter dans le sens indiqué par le mandant.
(*) Le texte des résolutions figure dans le dossier de convocation joint au présent formulaire (art R 225-81 du Code de Commerce) : ne pas utiliser à la fois « JE VOTE PAR CORRESPONDANCE » et « JE DONNE POUVOIR A » (art R 225-81 8° CC). La langue française fait foi.
 
NB : Si les informations contenues sur le présent formulaire sont utilisées pour un fichier nominatif informatisé, elles sont soumises aux prescriptions de la Loi 78-17 du 6 janvier 1978, notamment en ce qui concerne le droit d’accès et de rectification pouvant être exercé par l’intéressé.
 
INSTRUCTIONS FOR COMPLETION
 
A.      If the shareholder wishes to attend the meeting personally, tick box A on the front of the document. Please also date and sign at the bottom of the form.
B.      Otherwise, the shareholder may use this form as a postal vote (*).
          In this case, check box B on the front of the form and choose one of the three possibilities:
          - -use the postal voting form (tick the appropriate box, date and sign below)
          - -give your proxy to the Chairman of the meeting (date and just sign at the bottom without filling in)
          - -give your proxy to another shareholder (tick and fill in the appropriate box, date and sign below)
 
WHICHEVER OPTION IS USED the shareholder’s signature is necessary
(1) The shareholder should write his exact name and address in capital letters in the space provided: if this information is already supplied, please verify and correct if necessary. If the shareholder is a legal entity, the signatory should indicate his/her full name and the capacity in which he is entitled to sign on the legal entity’s behalf. If the signatory is not the shareholder (e.g. a legal guardian, etc.), please specify your full name and the capacity in which you are signing the proxy.
The forms sent for one meeting will be valid for all meetings subsequently convened with the same agenda (art. R 225-77§3 Code de Commerce ).
POSTAL VOTING FORM
(3) Art L. 225-107 of Code de Commerce (extract): “A shareholder can vote by post using a postal voting form determined by law.
Any other methods are deemed to be invalid”.
Only the forms received by the Company before the meeting, within the time limit and conditions determined by law, are valid to calculate the quorum.
The forms giving non voting directions or indicating abstention are deemed to vote against.
 
If you wish to use the postal voting form, you must tick the box on the front of the document "I VOTE BY POST”.
In such event, please comply with the following instructions:
For the resolutions proposed or agreed by the Board, you can:
- either vote “for” all the resolutions by leaving the boxes blank
- or vote “against” or “abstention” (which is equivalent to voting against) by shading boxes of your choice,
For the resolutions not agreed by the Board, you can:
- vote resolution by resolution by shading the appropriate boxes,
In the case of amendments or new resolutions during the shareholders’ meeting, you are requested to choose between three possibilities (proxy to the chairman of the meeting, abstention or proxy to another shareholder by shading the appropriate box.
PROXY TO THE CHAIRMAN OF THE MEETING OR PROXY TO ANOTHER SHAREHOLDER
(2) Art L. 225-106 of Code de Commerce (extract): "A shareholder can have himself/herself represented by another shareholder or by his/her spouse."
 
Any shareholder can receive proxies issued by the other shareholders to have themselves represented at a meeting, without any other limitations other than those laid down by the law or by the articles of association fixing the maximum number of votes to which a person is entitled both in his/her own name or a proxy. Before each shareholders’ meeting, the Chairman of the Board of Directors or the Executive Board may consult the shareholders listed in article L. 225-102 in order to allow them to designate one or several proxies to represent them at the shareholders’ meeting in accordance with this article. Such consultation is obligatory when the articles of association, having been modified pursuant to articles L. 225-23 or L. 225-71, require the shareholders’ ordinary meeting to appoint to the Board of Directors or the Executive Board, one or more shareholder employees or members of the Executive Board of a pension fund holding shares in the company. The clauses in contradiction with the provisions of the foregoing paragraphs are deemed to be invalid.
When proxies do not indicate the name of the appointed proxy, the chairman of the meeting will vote the proxy in favor of the adoption of the draft resolutions presented or approved by the Board of Directors or the Executive Board, and will vote the proxy against the adoption of all the other draft resolutions.  To give any other vote, the shareholder must choose a proxy who accepts to vote as he/she indicates.
(*) The text of the resolutions are in the notification of the meeting which is sent with this proxy (art R225-81 Code de Commerce) : please do not use both « I VOTE BY POST » and « I HEREBY APPOINT » (art R 225-81 8° CC). The French version of this document governs. The English translation is for convenience only.
 
NB : If any information included in this form is used for a computer file, it is protected by the provisions of law 78-17 of January 6, 1978, especially about rights of access and alteration that can be exercised by interested parties.
 
 

 

 
67988 Flamel
Egan / O’Brien
Proof 2
Control Number 67988


Flamel Technologies S.A.
 
 
 
 

WO# 75304
  FOLD AND DETACH HERE  
 

    
  
 
   
Please  mark your votes as 
indicated in this example
 x
The Board of Directors advise to vote in favor of all resolutions, except for resolution 14.
 
ORDINARY RESOLUTIONS
FOR
AGAINST
ABSTAIN
   
FOR
AGAINST
ABSTAIN
EXTRAORDINARY RESOLUTIONS
FOR
AGAINST
ABSTAIN
                             
1. 
Approval of Statutory Accounts for year ended December 31, 2009.
o 
o 
o
6.
Renewal of Mr. John L. Vogelstein as Director.
o
o
 
o 
11.
Authorization to be granted to the Board of Directors for allocation of seven hundred and fifty thousand (750,000) stock options and taking note
o
o
o
2.
Allocation of results to retained earnings.
o 
o
o
7.
Renewal of Mr Francis JT Fildes as Director.
o
o
o
 
of the resulting capital increases.
     
                             
3.
Renewal of Mr Elie Vannier as Director.
o
o
o
8.
Renewal of Mr. Stephen H. Willard as Director.
o
o
o
12.
Authorization to be granted to the Board of Directors with a view to allocation of two hundred thousand (200,000)
o
o
o
4.
Renewal of Mr. Frederic Lemoine as Director.
o
o
o
9.
Determination of the annual amount of Directors’ attendance fees.
o
o
o
  shares at no cost (“free shares”) and taking note of the resulting capital increases.      
                             
5.
Renewal of Mr Lodewijk J.R. De Vink as Director.
o
o
o
10.
Approval of agreements referred to in article L. 225-38 et seq. of the
Commercial Code.
o
o
o
13. 
Authorization to be granted to the Board of Directors for issue of a maximum number of two hundred and fifty thousand (250,000) stock warrants (BSA) reserved for a category of persons consisting of the company’s directors who are neither authorized agents nor employees of the company, but including the Chairman of the Board of Directors; authorization to be granted to the Board of Directors for carrying out the resulting capital increases.
o
o
o
                             
 
 
     
 
 
      14. 
Authorization to be granted to the Board of Directors for increasing the share capital by issues of shares reserved for the members of a company saving plan established in application of Articles L.3332-18 et seq. of the Labour Code.
 o
o
o
                             
  
 
     
 
 
      15. 
Powers for formalities.
o
o
o
             
       
 
 
RESTRICTED SCAN LINE AREA
 
  Mark Here for
  Address Change
  or Comments
  SEE REVERSE
o 
 
NOTE: Please sign as name appears hereon. Joint owners should each sign. When signing as attorney, executor, administrator, trustee or guardian, please give full title as such.
 
Signature 
 
 Signature 
 
 Date 
 

 
67988 Flamel
Egan / O’Brien
Proof 2
Control Number 67988
 
 
  
 
     
 
If no instructions are received by the Depositary from any Owner with respect to any of the Deposited Securities represented by the American Depositary Shares evidenced by such Owner’s Receipts on or before the date established by the Depositary for such purpose, the Depositary shall deem such Owner to have instructed the Depositary to vote such Deposited Securities and the Depositary shall vote such Deposited Securities in favor of any resolution proposed by the management of the Issuer and against any resolution not proposed by such management, except in case where (i) the Issuer does not wish such vote cast, (ii) substantial opposition exists or (iii) such matter materially and adversely affects the rights of holders of Shares or American Depositary Shares.
 
     
 
NOTE:
 
     
 
As registered owners of American Depositary Shares are not registered as holders of Shares on the registry maintained by or on behalf of Flamel Technologies, S.A., in accordance with French company law and the statuts of the Flamel Technologies S.A., registered owners of American Depositary Shares have no standing to (i) appear and vote at any meeting of holders of Shares, or (ii) propose any resolution at any shareholders’ meeting. If a holder of American Depositary Shares wishes to appear and vote at any meeting of the holders of Shares, or to propose any resolution at such meeting, such holder must surrender its receipts and withdraw the corresponding Deposited Securities pursuant to Section 2.5 of the Deposit Agreement and become registered on the registry maintained by or on behalf of Flamel Technologies S.A. at least (i) one (1) Paris Business Day prior to the date of the relevant shareholders’ meeting to appear and vote at such meeting, or (ii) twenty-five (25) calendar days prior to the date of the relevant shareholders’ meeting to propose any such resolution.
 
     
 
FOLD AND DETACH HERE
 
     
 
Flamel Technologies S.A.
 
 
Instructions to The Bank of New York Mellon, as Depositary
(Must be received prior to 5:00 p.m. on June 17, 2010)
 
     
 
The undersigned registered owner of American Depositary Shares hereby requests and instructs The Bank of New York Mellon, as Depositary, to endeavor, in so far as practicable, to vote or cause to be voted the amount of Ordinary Shares or other deposited securities represented by such American Depositary Shares registered in the name of the undersigned on the books of the Depositary as of the close of business on May 18, 2010 at the Combined Shareholders Meeting of Flamel Technologies S.A. to be held on June 25, 2010 in respect of the resolutions specified on the reverse.
 
 
NOTE:
 
 
Please direct the Depositary how it is to vote by placing an X in the appropriate box beside each resolution.
 
     
     
     
         
 
Address Change/Comments
(Mark the corresponding box on the reverse side)
 
BNY MELLON SHAREOWNER SERVICES
P.O. BOX 3549
S HACKENSACK NJ 07606-9249
 
         
     
(Continued and to be marked, dated and signed, on the other side)
 
         
     
WO#
 75304 
         

 
 

 
 
FLAMEL TECHNOLOGIES
Société Anonyme with a share capital of Euros 2,973,702
Registered Office :
Parc Club du Moulin à Vent
33, avenue du Docteur Georges Lévy
69693 VENISSIEUX (France)
 
379 001 530 R.C.S. LYON
 
DOCUMENT AND INFORMATION REQUEST FORM
Article R.225-81 of the French Code de Commerce

I, the undersigned:

_______________________________________ (first and last names and address) owner of __________(number of shares owned) registered shares of Flamel Technologies, a Société Anonyme with a share capital of Euros 2,973,702 having its registered office at Parc Club du Moulin à Vent, 33, avenue du Docteur Georges Lévy, 69693 VENISSIEUX (France), identified under number 379 001 530 R.C.S. LYON (the "Company"),

Hereby request that the documents referred to Art R.225-83 of the French Code de Commerce and relating to the combined ordinary and extraordinary meeting of the shareholders of the Company to be held at the registered office on June 25, 2010 at 11 a.m. (French time), be addressed to me at (address) ___________________________________________________________________________________________________ ..

In my capacity of owner of registered shares, I hereby also request in accordance with Article R.225-88 of the French Code de Commerce that a proxy form together with the documents and information set forth at Articles R.225-81 and R.225-83 of the French Code de Commerce be addressed to me on the occasion of each subsequent shareholders' meeting.*

I hereby declare that these shares are registered in an account held by CACEIS or Crédit Lyonnais**.

Done in _______________, on ___________

Signature of the shareholder

*To be deleted if not requested
** To be deleted if unuseful