SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13D
                                 Amendment No. 5

                    Under the Securities Exchange Act of 1934

                            Flamel Technologies S.A.
                           --------------------------
                                (Name of Issuer)

                                Ordinary Shares
                           --------------------------
                         (Title of Class of Securities)

                                   338488 10 9
                           --------------------------
                                 (CUSIP Number)

                                  Hilary Strain
                       One Embarcadero Center, Suite 4050
                             San Francisco, CA 94111
                                 (415) 362-4022
                           --------------------------
           (Name, Address and Telephone Number of Person Authorized to
                       Receive Notices and Communications)

                                October 2, 2003
                           --------------------------
             (Date of Event which Requires Filing of this Statement)

         If the filing person has  previously  filed a statement on Schedule 13G
to report the  acquisition  which is the subject of this  Schedule  13D,  and is
filing this schedule because of Rule 13d-1(b)(3) or (4), check the following box
[ ].

         Check the following box if a fee is being paid with this statement [ ].
(A fee  is not  required  only  if the  reporting  person:  (1)  has a  previous
statement on file  reporting  beneficial  ownership of more than five percent of
the class of  securities  described  in Item 1; and (2) has  filed no  amendment
subsequent  thereto  reporting  beneficial  ownership of five percent or less of
such class. (See Rule 13d-7).

         Note: Six copies of this statement,  including all exhibits,  should be
filed with the  Commission.  See Rule  13d-1(a) for other parties to whom copies
are to be sent.

         * The  remainder of this cover page shall be filled out for a reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

         The information  required on the remainder of this cover page shall not
be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
Act of 1934,  as  amended  (the  "Exchange  Act") or  otherwise  subject  to the
liabilities  of that  section  of the  Exchange  Act but shall be subject to all
other provisions of the Exchange Act.

                        (Continued on following page(s))

                               Page 1 of 16 Pages

CUSIP No. 0338488 10 9 13D Page 2 of 16 Pages - -------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta Partners - -------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a): (b) X - -------------------------------------------------------------------------------- (3) SEC Use Only - -------------------------------------------------------------------------------- (4) Source Of Funds* WC - -------------------------------------------------------------------------------- (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items 2(d) Or 2(e): - -------------------------------------------------------------------------------- (6) Citizenship Or Place Of Organization California - -------------------------------------------------------------------------------- Number Of Shares (7) Sole Voting Power -0- Beneficially Owned By Each Reporting Person With (8) Shared Voting Power -0- (9) Sole Dispositive Power -0- (10) Shared Dispositive Power -0- (11) Aggregate Amount Beneficially Owned By Each Reporting Person -0- Exit Filing - -------------------------------------------------------------------------------- (12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - -------------------------------------------------------------------------------- (13) Percent Of Class Represented By Amount In Row (11) 0% Exit Filing - -------------------------------------------------------------------------------- (14) Type Of Reporting Person CO - -------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!

CUSIP No. 0338488 10 9 13D Page 3 of 16 Pages - -------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta BioPharma Partners, L.P. - -------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a): (b) X - -------------------------------------------------------------------------------- (3) SEC Use Only - -------------------------------------------------------------------------------- (4) Source Of Funds* WC - -------------------------------------------------------------------------------- (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items 2(d) Or 2(e): - -------------------------------------------------------------------------------- (6) Citizenship Or Place Of Organization Delaware - -------------------------------------------------------------------------------- Number Of Shares (7) Sole Voting Power -0- Beneficially Owned By Each Reporting Person With (8) Shared Voting Power -0- (9) Sole Dispositive Power -0- (10) Shared Dispositive Power -0- (11) Aggregate Amount Beneficially Owned By Each Reporting Person -0- Exit Filing - -------------------------------------------------------------------------------- (12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - -------------------------------------------------------------------------------- (13) Percent Of Class Represented By Amount In Row (11) 0% Exit Filing - -------------------------------------------------------------------------------- (14) Type Of Reporting Person PN - -------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!

CUSIP No. 0338488 10 9 13D Page 4 of 16 Pages - -------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta Embarcadero BioPharma, LLC - -------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a): (b) X - -------------------------------------------------------------------------------- (3) SEC Use Only - -------------------------------------------------------------------------------- (4) Source Of Funds* WC - -------------------------------------------------------------------------------- (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items 2(d) Or 2(e): - -------------------------------------------------------------------------------- (6) Citizenship Or Place Of Organization California - -------------------------------------------------------------------------------- Number Of Shares (7) Sole Voting Power -0- Beneficially Owned By Each Reporting Person With (8) Shared Voting Power -0- (9) Sole Dispositive Power -0- (10) Shared Dispositive Power -0- (11) Aggregate Amount Beneficially Owned By Each Reporting Person -0- Exit Filing - -------------------------------------------------------------------------------- (12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - -------------------------------------------------------------------------------- (13) Percent Of Class Represented By Amount In Row (11) 0% Exit Filing - -------------------------------------------------------------------------------- (14) Type Of Reporting Person CO - -------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!

CUSIP No. 0338488 10 9 13D Page 5 of 16 Pages - -------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Flamel Chase Partners (Alta Bio), LLC - -------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a): (b) X - -------------------------------------------------------------------------------- (3) SEC Use Only - -------------------------------------------------------------------------------- (4) Source Of Funds* WC - -------------------------------------------------------------------------------- (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items 2(d) Or 2(e): - -------------------------------------------------------------------------------- (6) Citizenship Or Place Of Organization Delaware - -------------------------------------------------------------------------------- Number Of Shares (7) Sole Voting Power -0- Beneficially Owned By Each Reporting Person With (8) Shared Voting Power -0- (9) Sole Dispositive Power -0- (10) Shared Dispositive Power -0- (11) Aggregate Amount Beneficially Owned By Each Reporting Person -0- Exit Filing - -------------------------------------------------------------------------------- (12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - -------------------------------------------------------------------------------- (13) Percent Of Class Represented By Amount In Row (11) 0% Exit Filing - -------------------------------------------------------------------------------- (14) Type Of Reporting Person CO - -------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!

CUSIP No. 0338488 10 9 13D Page 6 of 16 Pages - -------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta BioPharma Management, LLC - -------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a): (b) X - -------------------------------------------------------------------------------- (3) SEC Use Only - -------------------------------------------------------------------------------- (4) Source Of Funds* WC - -------------------------------------------------------------------------------- (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items 2(d) Or 2(e): - -------------------------------------------------------------------------------- (6) Citizenship Or Place Of Organization Delaware - -------------------------------------------------------------------------------- Number Of Shares (7) Sole Voting Power -0- Beneficially Owned By Each Reporting Person With (8) Shared Voting Power -0- (9) Sole Dispositive Power -0- (10) Shared Dispositive Power -0- (11) Aggregate Amount Beneficially Owned By Each Reporting Person -0- Exit Filing - -------------------------------------------------------------------------------- (12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - -------------------------------------------------------------------------------- (13) Percent Of Class Represented By Amount In Row (11) 0% Exit Filing - -------------------------------------------------------------------------------- (14) Type Of Reporting Person CO - -------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!

CUSIP No. 0338488 10 9 13D Page 7 of 16 Pages - -------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta/Chase BioPharma Management, LLC - -------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a): (b) X - -------------------------------------------------------------------------------- (3) SEC Use Only - -------------------------------------------------------------------------------- (4) Source Of Funds* WC - -------------------------------------------------------------------------------- (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items 2(d) Or 2(e): - -------------------------------------------------------------------------------- (6) Citizenship Or Place Of Organization Delaware - -------------------------------------------------------------------------------- Number Of Shares (7) Sole Voting Power -0- Beneficially Owned By Each Reporting Person With (8) Shared Voting Power -0- (9) Sole Dispositive Power -0- (10) Shared Dispositive Power -0- (11) Aggregate Amount Beneficially Owned By Each Reporting Person -0- Exit Filing - -------------------------------------------------------------------------------- (12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - -------------------------------------------------------------------------------- (13) Percent Of Class Represented By Amount In Row (11) 0% Exit Filing - -------------------------------------------------------------------------------- (14) Type Of Reporting Person CO - -------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!

CUSIP No. 0338488 10 9 13D Page 8 of 16 Pages - -------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Jean Deleage - -------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a): (b) X - -------------------------------------------------------------------------------- (3) SEC Use Only - -------------------------------------------------------------------------------- (4) Source Of Funds* AF - -------------------------------------------------------------------------------- (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items 2(d) Or 2(e): - -------------------------------------------------------------------------------- (6) Citizenship Or Place Of Organization U.S.A. - -------------------------------------------------------------------------------- Number Of Shares (7) Sole Voting Power 1 Beneficially Owned By Each Reporting Person With (8) Shared Voting Power -0- Footnote 1 (9) Sole Dispositive Power 1 (10) Shared Dispositive Power -0- Footnote 1 (11) Aggregate Amount Beneficially Owned By Each Reporting Person 1 Please see Footnote 1 Exit Filing - -------------------------------------------------------------------------------- (12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - -------------------------------------------------------------------------------- (13) Percent Of Class Represented By Amount In Row (11) 0% Exit Filing - -------------------------------------------------------------------------------- (14) Type Of Reporting Person IN - -------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT! Footnote 7: Jean Deleage owns one share of Flamel Ordinary stock.

CUSIP No. 0338488 10 9 13D Page 9 of 16 Pages - -------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Garrett Gruener - -------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a): (b) X - -------------------------------------------------------------------------------- (3) SEC Use Only - -------------------------------------------------------------------------------- (4) Source Of Funds* AF - -------------------------------------------------------------------------------- (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items 2(d) Or 2(e): - -------------------------------------------------------------------------------- (6) Citizenship Or Place Of Organization U.S.A. - -------------------------------------------------------------------------------- Number Of Shares (7) Sole Voting Power -0- Beneficially Owned By Each Reporting Person With (8) Shared Voting Power -0- (9) Sole Dispositive Power -0- (10) Shared Dispositive Power -0- (11) Aggregate Amount Beneficially Owned By Each Reporting Person -0- Exit Filing - -------------------------------------------------------------------------------- (12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - -------------------------------------------------------------------------------- (13) Percent Of Class Represented By Amount In Row (11) 0% Exit Filing - -------------------------------------------------------------------------------- (14) Type Of Reporting Person IN - -------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!

CUSIP No. 0338488 10 9 13D Page 10 of 16 Pages - -------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Daniel Janney - -------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a): (b) X - -------------------------------------------------------------------------------- (3) SEC Use Only - -------------------------------------------------------------------------------- (4) Source Of Funds* AF - -------------------------------------------------------------------------------- (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items 2(d) Or 2(e): - -------------------------------------------------------------------------------- (6) Citizenship Or Place Of Organization U.S.A. - -------------------------------------------------------------------------------- Number Of Shares (7) Sole Voting Power -0- Beneficially Owned By Each Reporting Person With (8) Shared Voting Power -0- (9) Sole Dispositive Power -0- (10) Shared Dispositive Power -0- (11) Aggregate Amount Beneficially Owned By Each Reporting Person -0- Exit Filing - -------------------------------------------------------------------------------- (12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - -------------------------------------------------------------------------------- (13) Percent Of Class Represented By Amount In Row (11) 0% Exit Filing - -------------------------------------------------------------------------------- (14) Type Of Reporting Person IN - -------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!

CUSIP No. 0338488 10 9 13D Page 11 of 16 Pages - -------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alix Marduel - -------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a): (b) X - -------------------------------------------------------------------------------- (3) SEC Use Only - -------------------------------------------------------------------------------- (4) Source Of Funds* AF - -------------------------------------------------------------------------------- (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items 2(d) Or 2(e): - -------------------------------------------------------------------------------- (6) Citizenship Or Place Of Organization U.S.A. - -------------------------------------------------------------------------------- Number Of Shares (7) Sole Voting Power -0- Beneficially Owned By Each Reporting Person With (8) Shared Voting Power -0- (9) Sole Dispositive Power -0- (10) Shared Dispositive Power -0- (11) Aggregate Amount Beneficially Owned By Each Reporting Person -0- Exit Filing - -------------------------------------------------------------------------------- (12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - -------------------------------------------------------------------------------- (13) Percent Of Class Represented By Amount In Row (11) 0% Exit Filing - -------------------------------------------------------------------------------- (14) Type Of Reporting Person IN - -------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!

CUSIP No. 0338488 10 9 13D Page 12 of 16 Pages - -------------------------------------------------------------------------------- (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Guy Nohra - -------------------------------------------------------------------------------- (2) Check The Appropriate Box If A Member Of A Group (a): (b) X - -------------------------------------------------------------------------------- (3) SEC Use Only - -------------------------------------------------------------------------------- (4) Source Of Funds* AF - -------------------------------------------------------------------------------- (5) Check Box If Disclosure Of Legal Proceedings Is Required Pursuant To Items 2(d) Or 2(e): - -------------------------------------------------------------------------------- (6) Citizenship Or Place Of Organization U.S.A. - -------------------------------------------------------------------------------- Number Of Shares (7) Sole Voting Power -0- Beneficially Owned By Each Reporting Person With (8) Shared Voting Power -0- (9) Sole Dispositive Power -0- (10) Shared Dispositive Power -0- (11) Aggregate Amount Beneficially Owned By Each Reporting Person -0- Exit Filing - -------------------------------------------------------------------------------- (12) Check If The Aggregate Amount In Row (11) Excludes Certain Shares* - -------------------------------------------------------------------------------- (13) Percent Of Class Represented By Amount In Row (11) 0% Exit Filing - -------------------------------------------------------------------------------- (14) Type Of Reporting Person IN - -------------------------------------------------------------------------------- *SEE INSTRUCTION BEFORE FILLING OUT!

Item 1. Security and Issuer. This Statement on Schedule D relates to the Ordinary Shares, $0.080 French franc par value per share (the "Shares"), of Flamel Technologies, S.A., a French Societe Anonyme organized under the laws of The Republic of France (the "Company"). The principal executive offices of the Company are located at Parc Club Du Moulin a Vent, 33, avenue de Dr. Georges Levy, Venissieux, Cedex 69693, France. EXIT FILING --- On October 2 and 8, 2003, the funds affiliated with Alta Partners sold all its holdings in Flamel Technologies, S.A. Alta BioPharma Partners, L.P. sold 1,351,954 shares (exercised from warrants previously held and subsequently converted into ADS's) of the Issuers Ordinary Stock, Flamel Chase Partners (Alta Bio), LLC sold 772,088 shares (exercised from warrants previously held and subsequently converted into ADS's) of the Issuer's Ordinary Stock and Alta Embarcadero BioPharma Partners, LLC sold 50,958 shares (exercised from warrants previously held and subsequently converted into ADS's) of the Issuer's Ordinary Stock. Item 2. Identity and Background. (a) This Exit Filing is filed by (i) Alta BioPharma Partners, L.P., a Delaware limited partnership ("Alta BioPharma") by virtue of having been a record owner that sold its holdings of 1,351,954 shares (exercised from warrants previously held and subsequently converted into ADS's) of the Issuer's Ordinary Stock on October 2 and 8, 2003, (ii) Alta Embarcadero BioPharma Partners, LLC, a California limited liability company ("Embarcadero LLC") by virtue of having been a record owner that sold 50,958 shares (exercised from warrants previously held and subsequently converted into ADS's) of the Issuer's Ordinary Stock on October 2 and 8, 2003, and (iii) Flamel Chase Partners (Alta Bio), LLC, a Delaware limited liability company ("Flamel Alta Bio") by virtue of having been a record owner that sold its 772,088 shares (exercised from warrants previously held and subsequently converted into ADS's) of the Issuer's Ordinary Stock on October 2 and 8, 2003, and (iv) Alta BioPharma Management Partners, LLC, a Delaware limited liability company ("Alta Management"), by virtue of being the sole general partner of Alta BioPharma; (v) Alta/Chase BioPharma Management LLC, a Delaware limited liability company (Alta/Chase Management) by virtue of being the sole managing member of Flamel Chase Partners (Alta Bio), LLC and (vi) Alta Partners, a California corporation ("Alta Partners"), by virtue of being the management advisory company of these entities. Alta BioPharma, Embarcadero LLC, Flamel Alta Bio, Alta Management, Alta/Chase Management and Alta Partners are collectively referred to as the "Reporting Persons." Jean Deleage, Garrett Gruener, Daniel Janney, Alix Marduel, and Guy Nohra (the "Managing Directors") are the managing directors and members of Alta Management, Alta/Chase Management and officers of Alta Partners. By virtue of the relationships described above and their roles with Alta Partners, each of the managing directors and members may be deemed to control Alta Partners, Alta/Chase Management, Alta Management, and, therefore, may be deemed to possess indirect beneficial ownership of the shares held by each entity. However, none of the managing directors, acting alone, has voting or investment power with respect to the shares directly beneficially held by the entities and, as a result, the managing directors disclaim beneficial ownership of the shares beneficially owned by each entity, except to the extent of their proportionate pecuniary interests therein. Embarcadero LLC is a side company that makes all investments pro rata to the capital of Alta BioPharma with all allocations made to its members based on paid-in capital. Certain managing directors are members of Embarcadero LLC and certain members of Embarcadero LLC are affiliates of Alta Partners. (b) The principal executive offices of Alta BioPharma, Embarcadero LLC, Flamel Chase Alta Bio, Alta Management, Alta/Chase Management and Alta Partners, and the business address of each Partner, are located at One Embarcadero Center, Suite 4050, San Francisco, California 94111. (c) Alta Partners provides investment advisory services to venture capital firms. Alta BioPharma, Flamel Chase Alta Bio and Embarcadero LLC's principal business is acting as venture capital investment vehicles. Alta/Chase Management and Alta Management's principal business is acting as managing director of Flamel Chase Alta Bio and Alta BioPharma, respectively. Each of the Directors' principal business is acting as a managing director of Alta Management and Alta/Chase Management and as a director of Alta Partners. Page 13 of 16 Pages

(d) None of the Reporting Persons or, to the knowledge of the Reporting Persons, any of the managing directors, has been convicted in a criminal proceeding in the past five years (excluding traffic violations or similar misdemeanors). (e) During the past five years, none of the Reporting Persons or, to the knowledge of the Reporting Persons, and none of the managing directors, was a party to a civil proceeding of a judicial or administrative body of competent jurisdiction as a result of which such person was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws of finding any violation with respect to such laws. (f) Alta Partners is a California corporation. Alta BioPharma is a Delaware limited partnership. Embarcadero LLC is a California limited liability corporation. Flamel Chase Alta Bio is a Delaware limited liability company. Alta Management and Alta/Chase Management are Delaware limited liability companies. Each of the Managing Directors is a citizen of the United States. (g) Jean Deleage resigned his position as a Director of Flamel Technologies on August 13, 2001. Mr. Deleage owns one share of Ordinary Stock of Flamel Technologies stock. He is a managing director of Alta Management, Alta/Chase Management and a managing member of Embarcadero, LLC. By virtue of his roles with Alta Partners, he may be deemed to share control of Alta Partners, Alta/Chase Management, Alta Management, and, therefore, may be deemed to possess indirect beneficial ownership of the Shares held by each entity. However, he is not acting alone, he has voting or investment power with respect to the shares directly beneficially held by the entities and, as a result, he disclaims beneficial ownership of the shares directly beneficially owned by each entity, except to the extent of their pecuniary interest in each entity. Item 3. Source and Amount of Funds or Other Consideration. N/A Exit Filing --- On October 2 and 8, 2003, the funds affiliated with Alta Partners sold all their holdings in Flamel Technologies, S.A. Alta BioPharma Partners, L.P. sold 1,351,954 shares (exercised from warrants previously held and subsequently converted into ADS's) of the Issuer's Ordinary Stock, Flamel Chase Partners (Alta Bio), LLC sold 772,088 shares (exercised from warrants previously held and subsequently converted into ADS's) of the Issuer's Ordinary Stock, and Alta Embarcadero BioPharma Partners, LLC sold 50,958 shares (exercised from warrants previously held and subsequently converted into ADS's) of the Issuer's Ordinary Stock. Item 4. Purpose of Transaction. Exit Filing --- See Item 3 Item 5. Interest in Securities of the Issuer. Exit Filing Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to Securities of the Issuer. Exit Filing Item 7. Material to be Filed as Exhibits. Exhibit A: Joint Filing Statement Page 14 of 16 Pages

Signature After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Date: October 9, 2003 Alta Partners Alta BioPharma Partners, L.P. By: /s/ Jean Deleage By: Alta BioPharma Management, LLC -------------------------------------------- Its General Partner Jean Deleage, President Alta BioPharma Management, LLC By: /s/ Jean Deleage -------------------------------------------- Jean Deleage, Managing Director By: /s/ Jean Deleage Flamel Chase Partners (Alta Bio), LLC -------------------------------------------- Jean Deleage, Managing Director By: Alta/Chase BioPharma Management, LLC Alta/Chase BioPharma Management, LLC Its Managing Member By: /s/ Jean Deleage By: /s/ Jean Deleage -------------------------------------------- -------------------------------------------- Jean Deleage, Member Jean Deleage, Member Alta Embarcadero BioPharma Partners, LLC By: /s/ Jean Deleage -------------------------------------------- Jean Deleage, Member /s/ Jean Deleage /s/ Guy Nohra - ----------------------------------------------------- ----------------------------------------------------- Jean Deleage Guy Nohra /s/ Garrett Gruener /s/ Alix Marduel - ----------------------------------------------------- ----------------------------------------------------- Garrett Gruener Alix Marduel /s/ Daniel Janney - ----------------------------------------------------- Daniel Janney Page 15 of 16 Pages

EXHIBIT A Joint Filing Statement We, the undersigned, hereby express our agreement that the attached Schedule 13D is filed on behalf of each of us. Date: October 9, 2003 Alta Partners Alta BioPharma Partners, L.P. By: /s/ Jean Deleage By: Alta BioPharma Management, LLC -------------------------------------------- Its General Partner Jean Deleage, President Alta BioPharma Management, LLC By: /s/ Jean Deleage -------------------------------------------- Jean Deleage, Managing Director By: /s/ Jean Deleage Flamel Chase Partners (Alta Bio), LLC -------------------------------------------- Jean Deleage, Managing Director By: Alta/Chase BioPharma Management, LLC Alta/Chase BioPharma Management, LLC Its Managing Member By: /s/ Jean Deleage By: /s/ Jean Deleage -------------------------------------------- -------------------------------------------- Jean Deleage, Member Jean Deleage, Member Alta Embarcadero BioPharma Partners, LLC By: /s/ Jean Deleage -------------------------------------------- Jean Deleage, Member /s/ Jean Deleage /s/ Guy Nohra - ----------------------------------------------------- ----------------------------------------------------- Jean Deleage Guy Nohra /s/ Garrett Gruener /s/ Alix Marduel - ----------------------------------------------------- ----------------------------------------------------- Garrett Gruener Alix Marduel /s/ Daniel Janney - ----------------------------------------------------- Daniel Janney Page 16 of 16 Pages